THE ROLE OF ENDOGENOUS HYDROGEN SULFIDE IN THE REGULATION OF LIFE PROCESSE

The article considers the issues of biological role and medical significance of endogenous H₂S, previously considered exclusively toxic for humans – an environmental toxicant. The aspects of its metabolism in the body and regulation of formation with the help of H₂S donors and substances affecting the processes of biosynthesis of this gas transmitter are touched upon. The points of application and mechanisms of influence of H₂S on vital processes in norm and in pathological conditions are considered. The breadth of participation of H₂S in the regulation of metabolic reactions, physiological and pathological processes in the body allows us to consider this gas transmitter as a universal bioregulatory factor. Numerous studies have shown that both deficiency and excess of H₂S in the body can be associated with the occurrence and course of various disorders of vital activity, having both functional and organic nature, caused by chemical, physical, biological or purely informational factors. In this regard, various technologies are currently being actively developed aimed at preventing and correcting various life disorders using chemical instruments that regulate the level of endogenous hydrogen sulfide in the body, aimed at enhancing or suppressing its formation.

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