medjournalМедицинский журналMedical Journal1818-426XБелорусский государственный медицинский университет10.51922/1818-426X.2025.4.13medjournal-362Research ArticleОБЗОРЫ И ЛЕКЦИИREVIEWS AND LECTURESРоль эндогенного сероводорода в регуляции процессов жизнедеятельностиTHE ROLE OF ENDOGENOUS HYDROGEN SULFIDE IN THE REGULATION OF LIFE PROCESSEСемененяИ. Н.SemenenyaI. N.ПереверзевВ. А.PereverzevV. A.ЕвсеевА. В.EvseevA. V.

 г. Смоленск 

Smolensk

ГайковичЮ. В.HaikovichY. V.ПупаТ. А.PupaT. A.ШалаеваО. Е.ShalaevaO. E.

г. Смоленск

Smolensk

УО «Белорусский государственный медицинский университет»Educational Institution «Belarusian State Medical University»Федеральное государственное бюджетное образовательное учреждение высшего образования «Смоленский государственный медицинский университет»Federal State Budgetary Educational Institution of Higher Education «Smolensk State Medical University»202525122025041322Copyright © Семененя И.Н., Переверзев В.А., Евсеев А.В., Гайкович Ю.В., Пупа Т.А., Шалаева О.Е., 20252025Семененя И.Н., Переверзев В.А., Евсеев А.В., Гайкович Ю.В., Пупа Т.А., Шалаева О.Е.Semenenya I.N., Pereverzev V.A., Evseev A.V., Haikovich Y.V., Pupa T.A., Shalaeva O.E.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medjournal.ejournal.by/jour/article/view/362

Рассмотрены вопросы биологической роли и медицинского значения эндогенного H2S, ранее считавшегося исключительно токсическим для человека веществом – экологическим токсикантом. Затронуты аспекты его метаболизма в организме и регуляции образования с помощью доноров H2S и веществ, влияющих на процессы биосинтеза этого газотрансмиттера. Рассмотрены точки приложения и механизмы влияния H2S на процессы жизнедеятельности в норме и в условиях патологии. Широта участия H2S в регуляции метаболических реакций, физиологических и патологических процессов в организме позволяет рассматривать этот газотрансмиттер как универсальный биорегулирующий фактор. Многочисленными исследованиями показано, что, как недостаток, так и избыток H2S в организме может быть связан с возникновением и течением различных нарушений жизнедеятельности, имеющих как функциональную, так и органическую природу, вызванных химическими, физическими, биологическими или чисто информационными факторами. В связи с этим, в настоящее время активно разрабатываются различные технологии, направленные на предупреждение и коррекцию различных нарушений жизнедеятельности с использованием веществ, регулирующих уровень эндогенного сероводорода в организме, направленных на усиление или подавление его образования.

The article considers the issues of biological role and medical significance of endogenous H2S, previously considered exclusively toxic for humans – an environmental toxicant. The aspects of its metabolism in the body and regulation of formation with the help of H2S donors and substances affecting the processes of biosynthesis of this gas transmitter are touched upon. The points of application and mechanisms of influence of H2S on vital processes in norm and in pathological conditions are considered. The breadth of participation of H2S in the regulation of metabolic reactions, physiological and pathological processes in the body allows us to consider this gas transmitter as a universal bioregulatory factor. Numerous studies have shown that both deficiency and excess of H2S in the body can be associated with the occurrence and course of various disorders of vital activity, having both functional and organic nature, caused by chemical, physical, biological or purely informational factors. In this regard, various technologies are currently being actively developed aimed at preventing and correcting various life disorders using chemical instruments that regulate the level of endogenous hydrogen sulfide in the body, aimed at enhancing or suppressing its formation.

метаболизм эндогенного H2Sрегуляция образования H2Sроль H2S в физиологиироль H2S в патологииуправление жизнедеятельностью через H2Smetabolism of endogenous H2Sregulation of H2S formationrole of H2S in physiologylrole of H2S in pathologymanagement of life activity through H2SReferencesКолесников, С. И. Сероводород как третья эссенциальная газовая молекула живых тканей / С. И. Колесников, Б. Я. Власов, Л. И. Колесникова // Вестник РАМН. – 2015. – Т. 70, № 2. – С. 237–241. – doi: 10.15690/vramn.v70i2.1318.Kolesnikov, S. I. Serovodorod kak tretya essentsialnaya gazovaya molekula jivyih tkaney [Hydrogen Sulfide as a Third Essential Gas Molecule in Living Tissues] / S. I. Kolesnikov, B. Ya. Vlasov, L. I. Kolesnikova // Vestnik RAMN. – 2015. – Vol. 70, № 2. – P. 237–241. – doi: 10.15690/vramn.v70i2.1318 [in Russian].Зинчук, В. В. Кислородтранспортная функция крови и газотрансмиттер сероводород / В. В. Зинчук // Успехи физиол. наук. – 2021. – Т. 52, № 3. – С. 41–55. – doi: 10.31857/s0301179821030085.Zinchuk, V. V. Kislorodtransportnaya funktsiya krovi i gazotransmitter serovodorod [Oxygen transport function of blood and hydrogen sulfide gasоtransmitter] / V. V. Zinchuk // Uspehi fiziol. nauk. – 2021. – Vol. 52, № 3. – P. 41–55. – doi: 10.31857/s0301179821030085 [in Russian].In vivo monitoring of endogenous hydrogen sulfide and evaluation of natural protectants in liver injury mice using a highly selective bioluminescent probe / C. Hu, Z. Yang, X. Shi [et al.] // Biosens. Bioelectron. – 2025. – Vol. 278. – Р. 117343. – doi: 10.1016/j.bios.2025.117343.In vivo monitoring of endogenous hydrogen sulfide and evaluation of natural protectants in liver injury mice using a highly selective bioluminescent probe / C. Hu, Z. Yang, X. Shi [et al.] // Biosens. Bioelectron. – 2025. – Vol. 278. – P. 117343. – doi: 10.1016/j.bios.2025.117343.Яковлев, А. В. Физиологическая роль сероводорода в нервной системе / А. В. Яковлев, Г. Ф. Ситдикова // Гены и клетки. – 2014. – Т. 9, № 3. – С. 1–7.Yakovlev, A. V. Fiziologicheskaya rol serovodoroda v nervnoy sisteme [Physiological role of hydrogen sulfide in the nervous system] / A. V. Yakovlev, G. F. Sitdikova // Genyi i kletki. – 2014. – T. 9, № 3. – S. 1–7 [in Russian].Murros, K. E. Hydrogen sulfide produced by gut bacteria may induce Parkinson’s disease / K. E. Murros // Cells. – 2022. – Vol. 11, № 6. – P. 978. – doi: 10.3390/cells11060978.Murros, K. E. Hydrogen sulfide produced by gut bacteria may induce Parkinson’s disease / K. E. Murros // Cells. – 2022. – Vol. 11, № 6. – P. 978. – doi: 10.3390/cells11060978.Ju, Z. A highly selective fluorescent probe for hydrogen sulfide and its application in living cell / Z. Ju, Y. Zhang, L. Kong // J. Fluoresc. – 2025. – Vol. 35, № 2. – P. 1163–1169. – doi: 10.1007/s10895-024-03601-3.Ju, Z. A highly selective fluorescent probe for hydrogen sulfide and its application in living cell / Z. Ju, Y. Zhang, L. Kong // J. Fluoresc. – 2025. – Vol. 35, № 2. – P. 1163–1169. – doi: 10.1007/s10895-024-03601-3.Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharma cology and experimental validation / L. Yu, Q. Luo, X. Rao [et al.] // Sci. Rep. – 2025. – Vol. 15, № 1. – Р. 7410. – doi: 10.1038/s41598-025-91998-7.Unveiling the anti-inflammatory mechanism of exogenous hydrogen sulfide in Kawasaki disease based on network pharmacology and experimental validation / L. Yu, Q. Luo, X. Rao [et al.] // Sci. Rep. – 2025. – Vol. 15, № 1. – Р. 7410. – doi: 10.1038/s41598-025-91998-7.Roles of hydrogen sulfide (H2S) as a potential therapeutic agent in cardiovascular diseases: A narrative review / K. N. Islam, I. D. Nguyen, R. Islam [et al.] // Cureus. – 2024. – Vol. 16, № 7. – Р. e64913. – doi: 10.7759/cureus.64913.Roles of hydrogen sulfide (H2S) as a potential therapeutic agent in cardiovascular diseases: A narrative review / K. N. Islam, I. D. Nguyen, R. Islam [et al.] // Cureus. – 2024. – Vol. 16, № 7. – Р. e64913. – doi: 10.7759/cureus.64913.The therapeutic potential of hydrogen sulfide and its donors, a new discovery in vascular diseases / Y. Pu, W. Lin, S. Ren [et al.] // J. Cardiovasc. Pharmacol. – 2025. Epub ahead of print. – doi: 10.1097/FJC.0000000000001714.The therapeutic potential of hydrogen sulfide and its donors, a new discovery in vascular diseases / Y. Pu, W. Lin, S. Ren [et al.] // J. Cardiovasc. Pharmacol. – 2025. – Epub ahead of print. – doi: 10.1097/FJC.0000000000001714.Signaling paradigms of H2S-induced vasodilation: a comprehensive review / C. Munteanu, C. Popescu, A. Vlădulescu-Trandafir, G. Onose // Antioxidants (Basel). – 2024. – Vol. 13, № 10. – Р. 1158. – doi: 10.3390/antiox13101158.Signaling paradigms of H2S-induced vasodilation: a comprehensive review / C. Munteanu, C. Popescu, A. VlădulescuTrandafir, G. Onose // Antioxidants (Basel). – 2024. – Vol. 13, № 10. – Р. 1158. – doi: 10.3390/antiox13101158.Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation / Y. Zhang, X. Tian, L. Chen [et al.] // Redox. biol. – 2025. – Vol. 80. – Р. 103493. – doi: 10.1016/j.redox.2025.103493.Endogenous hydrogen sulfide persulfidates endothelin type A receptor to inhibit pulmonary arterial smooth muscle cell proliferation / Y. Zhang, X. Tian, L. Chen [et al.] // Redox. biol. – 2025. – Vol. 80. – Р. 103493. – doi: 10.1016/j.redox.2025.103493.Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation / X. X. Zhu, C. Y. Zhao, Q. B. Lu [et al.] // Front. Pharmacol. – 2025. – Vol. 16. – Р. 1510275. – doi: 10.3389/fphar.2025.1510275.Hydrogen sulfide as a new therapeutic target of pulmonary hypertension: an overview with update on immunomodulation / X. X. Zhu, C. Y. Zhao, Q. B. Lu [et al.] // Front. Pharmacol. – 2025. – Vol. 16. – Р. 1510275. – doi: 10.3389/fphar.2025.1510275.Pharmacology of hydrogen sulfide and its donors in cardiometabolic diseases / H. J. Sun, Q. B. Lu, X. X. Zhu [et al.] // Pharmacol. rev. – 2024. – Vol. 76, № 5. – P. 846–895. – doi: 10.1124/pharmrev.123.000928.Pharmacology of hydrogen sulfide and its donors in cardiometabolic diseases / H. J. Sun, Q. B. Lu, X. X. Zhu [et al.] // Pharmacol. rev. – 2024. – Vol. 76, № 5. – P. 846–895. – doi: 10.1124/pharmrev.123.000928.Cystathionine γ-lyase attenuates vascular smooth muscle cell senescence via Foxm1-Gas1 pathway to mediate arterial stiffness / Q. Lin, C. Cui, Y. Zhao [et al.] // Antioxid. Redox Signal. – 2025. – Vol. 42, № 13-15. – P. 655–671. – doi: 10.1089/ars.2024.0602.Cystathionine γ-lyase attenuates vascular smooth muscle cell senescence via Foxm1-Gas1 pathway to mediate arterial stiffness / Q. Lin, C. Cui, Y. Zhao [et al.] // Antioxid. Redox Signal. – 2025. – Vol. 42, № 13-15. – P. 655-671. – doi: 10.1089/ars.2024.0602.Содержание газотрансмиттеров в пуповинной крови и крови новорожденных, родившихся у матерей с преэклампсией / И. Г. Попова, О. Г. Ситникова, С. Б. Назаров [и др.] // Рос. вестн. перинатол. и педиатрии. – 2021. – Т. 66, № 4. – С. 53–57. – doi: org/10.21508/1027-4065-2021-66-4-53-57.Soderjanie gazotransmitterov v pupovinnoy krovi i krovi novorojdennyih, rodivshihsya u materey s preeklampsiey [The content of gas transmitters in umbilical cord blood and blood of newborns born to mothers with preeclampsia] / I. G. Popova, O. G. Sitnikova, S. B. Nazarov [et al.] // Ros. vestn. perinatol. i pediatrii. – 2021. – T. 66, № 4. – S. 53–57. – doi.org/10.21508/1027-4065-2021-66-4-53-57 [in Russian].Hydrogen sulfide: An endogenous regulator of the immune system / N. Dilek, A. Papapetropoulos, T. Toliver-Kinsky, C. Szabo // Pharmacol. Res. – 2020. – Vol. 161. – Epub 2020, Aug 8. – doi: 10.1016/j.phrs.2020.105119.Hydrogen sulfide: An endogenous regulator of the immune system / N. Dilek, A. Papapetropoulos, T. Toliver-Kinsky, C. Szabo // Pharmacol. Res. – 2020. – Vol. 161. – Epub 2020, Aug 8. – doi: 10.1016/j.phrs.2020.105119.Hydrogen sulfide promotes platelet autophagy via PDGFR-α/PI3K/Akt signaling in cirrhotic thrombocytopenia / H. X. Yang, Y. J. Li, Y. L. He [et al.] // J. clin. transl. hepatol. – 2024. – Vol. 12, № 7. – P. 625–633. – doi: 10.14218/JCTH.2024.00101.Hydrogen sulfide promotes platelet autophagy via PDGFR-α/PI3K/Akt signaling in cirrhotic thrombocytopenia / H. X. Yang, Y. J. Li, Y. L. He [et al.] // J. clin. transl. hepatol. – 2024. – Vol. 12, № 7. – P. 625–633. – doi: 10.14218/JCTH.2024.00101.Xu, S. Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis / S. Xu, Z. Liu, P. Liu // Int. J. Cardiol. – 2014. – Vol. 172, № 2. – P. 313–317. – doi: 10.1016/j.ijcard.2014.01.068.Xu, S. Targeting hydrogen sulfide as a promising therapeutic strategy for atherosclerosis / S. Xu, Z. Liu, P. Liu // Int. J.Cardiol. – 2014. – Vol. 172, № 2. – P. 313–317. – doi: 10.1016/j.ijcard.2014.01.068.Hydrogen sulfide mitigates ox-LDL-induced NLRP3/caspase-1/GSDMD dependent macrophage pyroptosis by S-sulfhydrating caspase-1 / Z. Jia, X. Zhang, Z. Li [et al.] // Mol. med. rep. – 2024. – Vol. 30, № 2. – P. 135. – doi: 10.3892/mmr.2024.13259.Hydrogen sulfide mitigates ox LDL induced NLRP3/ caspase 1/GSDMD dependent macrophage pyroptosis by S sulfhydrating caspase 1 / Z. Jia, X. Zhang, Z. Li [et al.] // Mol. med. rep. – 2024. – Vol. 30, № 2. – P. 135. – doi: 10.3892/mmr.2024.13259.LIFU-unlocked endogenous H2S generation for enhancing atherosclerosis-specific gas-enzymatic therapy / H. An, X. Qiu, X. Wang [et al.] // Biomaterials. – 2025. – Vol. 315. – Р. 122972. – doi: 10.1016/j.biomaterials.2024.122972.LIFU-unlocked endogenous H2S generation for enhancing atherosclerosis-specific gas-enzymatic therapy / H. An, X. Qiu, X. Wang [et al.] // Biomaterials. – 2025. – Vol. 315. – Р. 122972. – doi: 10.1016/j.biomaterials.2024.122972.H2S donor SPRC ameliorates cardiac aging by suppression of JMJD3, a histone demethylase / S. Li, Q. Li, H. Xiang [et al.] // Antioxid. Redox Signal. – 2025. – Vol. 42, № 7-9. – P. 301–320. – doi: 10.1089/ars.2024.0605.H2S donor SPRC ameliorates cardiac aging by suppression of JMJD3, a histone demethylase / S. Li, Q. Li, H. Xiang [et al.] // Antioxid. Redox Signal. – 2025. – Vol. 42, № 7-9. – P. 301–320. – doi: 10.1089/ars.2024.0605.Szabo, C. Hydrogen sulfide, an endogenous stimulator of mitochondrial function in cancer cells / C. Szabo // Cells. – 2021. – Vol. 10, № 2. – P. 220. – doi: 10.3390/cells10020220.Szabo, C. Hydrogen sulfide, an endogenous stimulator of mitochondrial function in cancer cells / C. Szabo // Cells. – 2021. – Vol. 10, № 2. – P. 220. – doi: 10.3390/cells10020220.Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of coldinducible RNA-binding protein / D. Li, S. Jin, X. Teng [et al.] // Biosci. Rep. – 2025. – Vol. 45, № 2. – Р. BSR20241398. – doi: 10.1042/BSR20241398.Hydrogen sulfide attenuates sepsis-induced cardiac dysfunction in infant rats by inhibiting the expression of coldinducible RNA-binding protein / D. Li, S. Jin, X. Teng [et al.] // Biosci. Rep. – 2025. – Vol. 45, № 2. – Р. BSR20241398. – doi: 10.1042/BSR20241398.Hydrogen sulfide (H2S) mitigates sepsis-induced adrenal dysfunction via inhibition of TNFα-mediated necroptosis / K. Ma, J. Huang, J. Zhang [et al.] // Pathogens. – 2025. – Vol. 14, № 5. – P. 439. – doi: 10.3390/pathogens14050439.Hydrogen sulfide (H2S) mitigates sepsis-induced adrenal dysfunction via inhibition of TNFα-mediated necroptosis / K. Ma, J. Huang, J. Zhang [et al.] // Pathogens. – 2025. – Vol. 14, № 5. – P. 439. – doi: 10.3390/pathogens14050439.Lu, W. Anti-inflammatory effects of hydrogen sulfide in axes between gut and other organs / W. Lu, J. Wen // Antioxid. Redox Signal. – 2025. – Vol. 42, № 7-9. – P. 341–360. – doi: 10.1089/ars.2023.0531.Lu, W. Anti-inflammatory effects of hydrogen sulfide in axes between gut and other organs / W. Lu, J. Wen // Antioxid. Redox Signal. – 2025. – Vol. 42, № 7-9. – P. 341–360. – doi: 10.1089/ars.2023.0531.Paul, B. D. Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease / B. D. Paul, A. A. Pieper // Curr. opin. chem. biol. – 2024. – Vol. 82. – Р. 102511. – doi: 10.1016/j.cbpa.2024.102511.Paul, B. D. Neuroprotective signaling by hydrogen sulfide and its dysregulation in Alzheimer's disease / B. D. Paul, A. A. Pieper // Curr. opin. chem. biol. – 2024. – Vol. 82. – Р. 102511. – doi: 10.1016/j.cbpa.2024.102511.Inhibited endogenous H2S generation and excessive autophagy in hippocampus contribute to sleep deprivation-induced cognitive impairment / S. Q. Yang, L. Jiang, F. Lan [et al.] // Front. Psychol. – 2019. – Vol. 10. – Р. 53. – doi: 10.3389/fpsyg.2019.00053.Inhibited endogenous H2S generation and excessive autophagy in hippocampus contribute to sleep deprivation-induced cognitive impairment / S. Q. Yang, L. Jiang, F. Lan [et al.] // Front. Psychol. – 2019. – Vol. 10. – Р. 53. – doi: 10.3389/fpsyg.2019.00053.Critical role of hydrogen sulfide in the management of neurodegenerative disease / R. Pawar, D. Pandey, S. Naqvi, A. Sharma // Nitric Oxide. – 2025. – Vol. 154. – P. 77–85. – doi: 10.1016/j.niox.2024.11.006.Critical role of hydrogen sulfide in the management of neurodegenerative disease / R. Pawar, D. Pandey, S. Naqvi, A. Sharma // Nitric Oxide. – 2025. – Vol. 154. – P. 77–85. – doi: 10.1016/j.niox.2024.11.006.Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathology / P. K. Kamat, A. Kalani, N. Debnath [et al.] // Geroscience. – 2025. – Epub ahead of print. – doi: 10.1007/s11357-025-01662-1.Neuroprotective mechanism of hydrogen sulfide in okadaic acid-induced alzheimer-like pathology / P. K. Kamat, A. Kalani, N. Debnath [et al.] // Geroscience. – 2025. – Epub ahead of print. – doi: 10.1007/s11357-025-01662-1.Hydrogen sulfide and its donors for the treatment of traumatic brain injury: A comprehensive review / X. Li, Y. An, M. Xu [et al.] // Int. J. Pharm. – 2025. – Vol. 680. – Р. 125792. – Epub ahead of print. – doi: 10.1016/j.ijpharm.2025.125792.Hydrogen sulfide and its donors for the treatment of traumatic brain injury: A comprehensive review / X. Li, Y. An, M. Xu [et al.] // Int. J. Pharm. – 2025. – Vol. 680. – Р. 125792. – Epub ahead of print. – doi: 10.1016/j.ijpharm. 2025.125792.Elucidating the significance of endogenous hydrogen sulfide as a novel candidate for postoperative pain recovery in a murine model / J. L. Dallazen, L. G. Santos, S. A. Teixeira [et al.] // Eur. J. Pain. – 2025. – Vol. 29, № 6. – Р. e70043. – doi: 10.1002/ejp.70043.Elucidating the significance of endogenous hydrogen sulfide as a novel candidate for postoperative pain recovery in a murine model / J. L. Dallazen, L. G. Santos, S. A. Teixeira [et al.] // Eur. J. Pain. – 2025. – Vol. 29, № 6. – Р. e70043. – doi: 10.1002/ejp.70043.Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice / S. A. Coavoy-Sánchez, L. Rodrigues, S. A. Teixeira [et al.] // Pharmacol. Res. – 2016. – Vol. 113, Pt A. – P. 686–694. – doi: 10.1016/j.phrs.2016.09.030.Hydrogen sulfide donors alleviate itch secondary to the activation of type-2 protease activated receptors (PAR-2) in mice / S. A. Coavoy-Sánchez, L. Rodrigues, S. A. Teixeira [et al.] // Pharmacol. Res. – 2016. – Vol. 113, Pt A. – P. 686–694. – doi: 10.1016/j.phrs.2016.09.030.S-allyl-cysteine ameliorates cirrhotic portal hypertension by enhancing lymphangiogenesis via a VEGF-C-independent manner / G. Luo, Z. Wu, Q. Fan [et al.] // Liver Int. – 2025. – Vol. 45, № 3. – Р. e70024. – doi: 10.1111/liv.70024.S-allyl-cysteine ameliorates cirrhotic portal hypertension by enhancing lymphangiogenesis via a VEGF-C-independent manner / G. Luo, Z. Wu, Q. Fan [et al.] // Liver Int. – 2025. – Vol. 45, № 3. – Р. e70024. – doi: 10.1111/liv.70024.Abdel-Hamid, H. A. Hydrogen sulfide protects the endometrium in a rat model of type 1 diabetes via modulation of PPARγ/mTOR and Nrf-2/NF-κb pathways / H. A. Abdel-Hamid, H. Marey, M. F. G. Ibrahim // Arch. Physiol. Biochem. – 2024. – Vol. 130, № 6. – P. 909–920. – doi: 10.1080/13813455.2024.2347239.Abdel-Hamid, H. A. Hydrogen sulfide protects the endometrium in a rat model of type 1 diabetes via modulation of PPARγ/mTOR and Nrf-2/NF-κb pathways / H. A. Abdel-Hamid, H. Marey, M. F. G. Ibrahim // Arch. Physiol. Biochem. – 2024. – Vol. 130, № 6. – P. 909–920. – doi: 10.1080/13813455.2024.2347239.Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes / X. Fang, J. Wang, C. Ye [et al.] // Nat. commun. – 2024. – Vol. 15, № 1. – P. 9071. – doi: 10.1038/s41467-024-53290-6.Polyphenol-mediated redox-active hydrogel with H2S gaseous-bioelectric coupling for periodontal bone healing in diabetes / X. Fang, J. Wang, C. Ye [et al.] // Nat. commun. – 2024. – Vol. 15, № 1. – P. 9071. – doi: 10.1038/s41467-024-53290-6.An injectable and adaptable system for the sustained release of hydrogen sulfide for targeted diabetic wound therapy by improving the microenvironment of inflammation regulation and angiogenesis / H. Zhang, X. Dong, Y. Liu [et al.] // Acta Biomater. – 2025. – Vol. 196. – P. 364–379. – doi: 10.1016/j.actbio.2025.02.048.An injectable and adaptable system for the sustained release of hydrogen sulfide for targeted diabetic wound therapy by improving the microenvironment of inflammation regulation and angiogenesis / H. Zhang, X. Dong, Y. Liu [et al.] // Acta Biomater. – 2025. – Vol. 196. – P. 364–379. – doi: 10.1016/j.actbio.2025.02.048.Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels / S. Zhou, L. Zheng, T. Zheng [et al.] // Front. Pharmacol. – 2024. – Vol. 15. – Р. 1447249. – doi: 10.3389/fphar.2024.1447249.Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels / S. Zhou, L. Zheng, T. Zheng [et al.] // Front. Pharmacol. – 2024. – Vol. 15. – Р. 1447249. – doi: 10.3389/fphar.2024.1447249.Isorhamnetin alleviates renal fibrosis by inducing endogenous hydrogen sulfide and regulating thiol-based redox state in obstructed kidneys / Z. Zhang, H. Zhang, J. Shi [et al.] // Biomolecules. – 2024. – Vol. 14, № 10. – P. 1233. – doi: 10.3390/biom14101233.Isorhamnetin alleviates renal fibrosis by inducing endogenous hydrogen sulfide and regulating thiol-based redox state in obstructed kidneys / Z. Zhang, H. Zhang, J. Shi [et al.] // Biomolecules. – 2024. – Vol. 14, № 10. – P. 1233. – doi: 10.3390/biom14101233.The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present / S. Salehiyeh, A. F. Faiz, M. Manzourolhojeh [et al.] // Naunyn schmiedebergs arch. pharmacol. – 2024. – Vol. 397, № 9. – P. 6391–6415. – doi: 10.1007/s00210-024-03086-8.The functions of hydrogen sulfide on the urogenital system of both males and females: from inception to the present / S. Salehiyeh, A. F. Faiz, M. Manzourolhojeh [et al.] // Naunyn schmiedebergs arch. pharmacol. – 2024. – Vol. 397, № 9. – P. 6391–6415. – doi: 10.1007/s00210-024-03086-8.Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis / Z. Mao, P. Chen, Q. Ji [et al.] // Front. Pharmacol. – 2025. – Vol. 16. – Р. 1562852. – doi: 10.3389/fphar.2025.1562852.Hydrogen sulfide and ferroptosis inhibition underlies the dietary restriction-induced protection against cyclophosphamide cystitis / Z. Mao, P. Chen, Q. Ji [et al.] // Front. Pharmacol. – 2025. – Vol. 16. – Р. 1562852. – doi: 10.3389/fphar.2025.1562852.Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction / Z. Pilsova, A. Pilsova, N. Zelenkova [et al.] // Front. endocrinol. (Lausanne). – 2024. – Vol. 15. – Р. 1427069. – doi: 10.3389/fendo.2024.1427069.Hydrogen sulfide and its potential as a possible therapeutic agent in male reproduction / Z. Pilsova, A. Pilsova, N. Zelenkova [et al.] // Front. endocrinol. (Lausanne). – 2024. – Vol. 15. – Р. 1427069. – doi: 10.3389/fendo.2024.1427069.Hydrogen sulfide protects against toxicant acroleininduced ferroptotic cell death in Sertoli cells / Z. Mao, Q. Ji, P. Chen [et al.] // Front. Pharmacol. – 2024. – Vol. 15. – Р. 1440147. – doi: 10.3389/fphar.2024.1440147.Hydrogen sulfide protects against toxicant acroleininduced ferroptotic cell death in Sertoli cells / Z. Mao, Q. Ji, P. Chen [et al.] // Front. Pharmacol. – 2024. – Vol. 15. – Р. 1440147. – doi: 10.3389/fphar.2024.1440147.Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans / A. R. Vintila, L. Slade, M. Cooke [et al.] // PNAS. – 2023. – Vol. 120, № 32. – Р. e2216141120. – doi: 10.1073/pnas.2216141120.Mitochondrial sulfide promotes life span and health span through distinct mechanisms in developing versus adult treated Caenorhabditis elegans / A. R. Vintila, L. Slade, M. Cooke [et al.] // PNAS. – 2023. – Vol. 120, № 32. – Р. e2216141120. – doi: 10.1073/pnas.2216141120.H2S: a universal defense against antibiotics in bacteria / K. Shatalin, E. Shatalina, A. Mironov, E. Nudler // Science. – 2011. – Vol. 334, № 6058. – P. 986–990. – doi: 10.1126/science.1209855.H2S: a universal defense against antibiotics in bacteria / K. Shatalin, E. Shatalina, A. Mironov, E. Nudler // Science. – 2011. – Vol. 334, № 6058. – P. 986–990. – doi: 10.1126/science.1209855.Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARS-CoV-2 infection / R. Agrawal, V. K. Pal, S. S. K [et al.] // PLoS Pathog. – 2025. – Vol. 21, № 5. – Р. e1013164. – doi: 10.1371/journal.ppat.1013164.Hydrogen sulfide (H2S) coordinates redox balance, carbon metabolism, and mitochondrial bioenergetics to suppress SARSCoV-2 infection / R. Agrawal, V. K. Pal [et al.] // PLoS Pathog. – 2025. – Vol. 21, № 5. – Р. e1013164. – doi: 10.1371/journal.ppat.1013164.Engineered probiotics enable targeted gut delivery of dual gasotransmitters for inflammatory bowel disease therapy / T. Ma, G. Gan, J. Cheng [et al.] // Angew. Chem. Int. Ed Engl. – 2025. – Vol. 64, № 22. – Р. e202502588. – doi: 10.1002/anie.202502588.Engineered probiotics enable targeted gut delivery of dual gasotransmitters for inflammatory bowel disease therapy / T. Ma, G. Gan, J. Cheng [et al.] // Angew. Chem. Int. Ed Engl. – 2025. – Vol. 64, № 22. – Р. e202502588. – doi: 10.1002/anie.202502588.Emerging roles of hydrogen sulfide in colorectal cancer / Z. L. Jiang, Y. Liu, C. H. Zhang [et al.] // Chem. biol. interact. – 2024. – Vol. 403. – Р. 111226. – doi: 10.1016/j.cbi.2024.111226.Emerging roles of hydrogen sulfide in colorectal cancer / Z. L. Jiang, Y. Liu, C. H. Zhang [et al.] // Chem. biol. interact. – 2024. – Vol. 403. – Р. 111226. – doi: 10.1016/j.cbi.2024.111226.Role of hydrogen sulfide-microRNA crosstalk in health and disease / M. R. Jing, X. Y. Liang, Y. X. Zhang [et al.] // Nitric oxide. – 2024. – Vol. 152. – P. 19–30. – doi: 10.1016/j.niox.2024.09.002.Role of hydrogen sulfide-microRNA crosstalk in health and disease / M. R. Jing, X. Y. Liang, Y. X. Zhang [et al.] // Nitric oxide. – 2024. – Vol. 152. – P. 19–30. – doi: 10.1016/j.niox.2024.09.002.H2S-Prdx4 axis mitigates Golgi stress to bolster tumorreactive T cell immunotherapeutic response / N. Oberholtzer, P. Chakraborty, M. F. Kassir [et al.] // Sci. Adv. – 2024. – Vol. 10, № 46. – Р. eadp1152. – doi: 10.1126/sciadv.adp1152.H2S-Prdx4 axis mitigates Golgi stress to bolster tumorreactive T cell immunotherapeutic response / N. Oberholtzer, P. Chakraborty, M. F. Kassir [et al.] // Sci. Adv. – 2024. – Vol. 10, № 46. – Р. eadp1152. – doi: 10.1126/sciadv.adp1152.Exploring the impact of hydrogen sulfide on hematologic malignancies: a review / S. Lou, Z. L. Jiang, Y. W. Zhu [et al.] // Cell. Signal. – 2024. – Vol. 120. – Р. 111236. – doi: 10.1016/j.cellsig.2024.111236.Exploring the impact of hydrogen sulfide on hematologic malignancies: a review / S. Lou, Z. L. Jiang, Y. W. Zhu [et al.] // Cell. Signal. – 2024. – Vol. 120. – Р. 111236. – doi: 10.1016/j.cellsig.2024.111236.

The authors declare that there are no conflicts of interest present.