Laser-beam destruction of perforating veins in combination with autotransplantation of dermal fibroblasts in the complex treatment of venous trophic ulcers of the lower extremities

Elimination of the etiopathogenetic factor plays a key role in the treatment of venous trophic ulcers. Currently, preference is given to operations using laser energy. Also, at present, in the treatment of trophic ulcers and long-term non-healing wounds, methods of cell transplantation and cell therapy are being actively researched and implemented. The use of methods of cell transplantation and cell therapy, according to the authors, can accelerate the healing of trophic ulcers and reduce the risk of recurrence.

Goal and objectives. To introduce into clinical practice and evaluate the results of the elimination of vertical and horizontal venous reflux by endovenous laser-beam coagulation in combination with autotransplantation of dermal fibroblasts in patients with venous trophic ulcers.

Materials and methods. Surgical correction of venous reflux with following autotransplantation of dermal fibroblasts was carried out in 18 patients with trophic ulcers of venous etiology during 2018–2022.

Results and its discussion. The effect of usage of autologous dermal fibroblasts was registered in 100 % of cases. All 18 patients achieved complete healing of ulcers within 2 to 4 weeks after cell transplantation. Patients were examined 1 year after cell autotransplantation. There were no recurrences of trophic ulcers.

Conclusions. The usage of laser-beam methods for correction of venous reflux in combi- nation with autotransplantation of dermal fibroblasts made it possible to achieve complete healing of ulcerous defect in patients with trophic ulcers of venous etiology. When evaluating long-term results, the absence of relapses was also noted in 100 % of cases.

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