Assessment of clinical and laboratory characteristics in patients with severe COVID-19 infection: focus on hospital hyperglycemia
https://doi.org/10.51922/1818-426X.2023.2.113
Abstract
The article presents the results of our own studies of clinical, anamnestic and laboratory parameters in patients with severe COVID-19. The aim of the study was to identify possible clinical and laboratory predictors of an unfavorable outcome of a severe course of Covid-19 in patients with diabetes mellitus and hyperglycemia. A retrospective analysis of data from primary medical records of 320 patients was performed. All patients received medical care in the intensive care unit of the infectious hospital in Minsk from June 2020 to March 2022. Based on the results of the assessment of glycemic parameters, all patients were divided into the following groups: 224 people with hospital hyperglycemia (HH), 51 patients with a history of diabetes mellitus (DM) and/or newly diagnosed and 45 people without glycemic disorders. Covid-19 infection confirmed by a positive PCR or antigen test from respiratory swabs. Patients with HH and DM had higher levels of ESR, procalcitonin, CRP, LDH, neutrophils, more pronounced lymphopenia, which indicated a more pronounced inflammatory process. The level of D-dimers was assessed as a biomarker of the coagulopathy process, it was also higher in the groups of patients with DM and HH. According to the results of the study, 70 % of patients with severe COVID-19 had newly diagnosed hyperglycemia, and from day 4, patients with an unfavorable outcome showed a tendency to persistent hyperglycemia, which potentially indicates its role as a prognostic parameter.
About the Authors
A. P. Shepelkevich
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
M. A. Efremova
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
Y. V. Dydyshko
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
I. A. Karpov
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
D. V. Litvinchuk
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
E. V. Yurenya
УЗ «Минский городской клинический эндокринологический центр»
Belarus
Belarus
O. N. Shishko
УЗ «Минский городской клинический эндокринологический центр»
Belarus
Belarus
E. I. Kuzmenkova
ГУ «Республиканский центр медицинской реабилитации и бальнеолечения»
Belarus
Belarus
E. V. Brutskaya-Stempkovskaya
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
V. L. Lobashova
ГУ «Республиканский центр медицинской реабилитации и бальнеолечения»
Belarus
Belarus
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Review
For citations:
Shepelkevich A.P., Efremova M.A., Dydyshko Y.V., Karpov I.A., Litvinchuk D.V., Yurenya E.V., Shishko O.N., Kuzmenkova E.I., Brutskaya-Stempkovskaya E.V., Lobashova V.L. Assessment of clinical and laboratory characteristics in patients with severe COVID-19 infection: focus on hospital hyperglycemia. Medical Journal. 2023;(2):113-119. (In Russ.) https://doi.org/10.51922/1818-426X.2023.2.113
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