Clinical case of congenital chloride diarrhea
https://doi.org/10.51922/1818-426X.2022.4.114
Abstract
Congenital chloride diarrhea (CCD, congenital chloridorrhea and syndrome Darrow-Gamble) is variant of a severe syndrome of electrolyte malabsorption transmitted by autosomal recessive inheritance and manifested by profuse watery stool with massive loss of chlorides and dehydration. Newborn children with CCD need adequate replacement treatment from the first hours of life to prevent electrolyte disorders and dehydration. However, CCD cases, when newborn babies survived even without therapy, were described. But further growth delay, retardation of psychomotor development, nephropathy and hyperaldosteronism was observed as a result of hypochloremia, hypokalemia and metabolic alkalosis. The article describes a pathogenesis, clinical picture, diagnostic criteria, symptomatic therapy and results of our own observation of patient with CCD.
About the Authors
I. A. Kazyra
Белорусский государственный медицинский университет
Belarus
Belarus
A. G. Bialkevich
Белорусский государственный медицинский университет
Russian Federation
Russian Federation
Y. L. Shynkarenka
2-я городская детская клиническая больница
Russian Federation
Russian Federation
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For citations:
Kazyra I.A., Bialkevich A.G., Shynkarenka Y.L. Clinical case of congenital chloride diarrhea. Medical Journal. 2022;(4):114-120. (In Russ.) https://doi.org/10.51922/1818-426X.2022.4.114
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