Полные особенности психических расстройств у женщин: гормональные, психологические и биологические аспекты

В статье представлен систематический анализ полных особенностей психических расстройств у женщин. Рассматривается роль гормональных факторов (эстрогены, прогестерон, кортизол) в патогенезе аффективных, тревожных, пищевых и других расстройств. Описываются психологические особенности женского реагирования – руминации, созависимость, склонность к интернализации эмоций. Анализируются критические периоды женского репродуктивного цикла (предменструальный синдром, перинатальный период, менопауза), в которые риск манифестации или декомпенсации психических расстройств значительно возрастает. Обосновывается необходимость полно-ориентированных подходов в психиатрической практике.

1. Ангст, Дж. Коморбидные расстройства у пациентов с большой депрессией: клиническое значение // Психиатрия и психофармакотерапия. – 2002. – Т. 4, № 5. – С. 180–185

2. Миронова, О. И., Резниченко С. И. Ролевые конфликты и психическое здоровье работающих женщин // Психологические исследования. – 2020. – Т. 13, № 70. – С. 7. – URL: http://psystudy.ru (дата обращения: 10.04.2025)

3. Тювина, Н. А. Полные особенности психических заболеваний // Неврология, нейропсихиатрия, психосоматика. – 2017. – Т. 9, № 2. – С. 4–10

4. Aleman, A., Kahn R. S., Selten J. P. Sex differences in the risk of schizophrenia: evidence from meta-analysis // Archives of General Psychiatry. – 2003. – Vol. 60, № 6. – P. 565–571.

5. Angst, J., Gamma A., Gastpar M. et al. Gender differences in depression. Epidemiological findings from the European DEPRES I and II studies // European Archives of Psychiatry and Clinical Neuroscience. – 2002. – Vol. 252, № 5. – P. 201–209.

6. Bäckström, T., Bixo M., Johansson M. et al. Allopregnanolone and mood disorders // Progress in Neurobiology. – 2014. – Vol. 113. – P. 88–94.

7. Bandelow, B., Michaelis S. Epidemiology of anxiety disorders in the 21st century // Dialogues in Clinical Neuroscience. – 2015. – Vol. 17, № 3. – P. 327–335.

8. Bloch, M., Schmidt P. J., Danaceau M. et al. Effects of gonadal steroids in women with a history of postpartum depression // American Journal of Psychiatry. – 2000. – Vol. 157, № 6. – P. 924–930.

9. Breslau, N., Davis G. C., Andreski P. et al. Sex differences in posttraumatic stress disorder // Archives of General Psychiatry. – 1997. – Vol. 54, № 11. – P. 1044–1048.

10. Brinton, R. D., Yao J., Yin F. et al. Perimenopause as a neurological transition state // Nature Reviews Endocrinology. – 2015. – Vol. 11, № 7. – P. 393–405.

11. Cohen, L. S., Soares C. N., Vitonis A. F. et al. Risk for new onset of depression during the menopausal transition // Archives of General Psychiatry. – 2006. – Vol. 63, № 4. – P. 385–390.

12. Cyranowski, J. M., Frank E., Young E. et al. Adolescent onset of the gender difference in lifetime rates of major depression // Archives of General Psychiatry. – 2000. – Vol. 57, № 1. – P. 21–27.

13. Epperson, C. N., Steiner M., Hartlage S. A. et al. Premenstrual dysphoric disorder: evidence for a new category for DSM-5 // American Journal of Psychiatry. – 2012. – Vol. 169, № 5. – P. 465–475.

14. Fairburn, C. G., Cooper Z., Doll H. A. et al. Risk factors for anorexia nervosa: three integrated case-control comparisons // Archives of General Psychiatry. – 1999. – Vol. 56, № 5. – P. 468–476.

15. Gavin, N. I., Gaynes B. N., Lohr K. N. et al. Perinatal depression: a systematic review of prevalence and incidence // Obstetrics & Gynecology. – 2005. – Vol. 106, № 5. – P. 1071–1083.

16. Genazzani, A. R., Pluchino N., Luisi S. et al. Estrogen, cognition and woman’s risk of Alzheimer’s disease // Human Reproduction Update. – 2007. – Vol. 13, № 2. – P. 175–187.

17. Grabe, S., Ward L. M., Hyde J. S. The role of the media in body image concerns among women: a meta-analysis of experimental and correlational studies // Psychological Bulletin. – 2008. – Vol. 134, № 3. – P. 460–476.

18. Grant, B. F., Chou S. P., Goldstein R. B. et al. Prevalence, correlates, disability, and comorbidity of DSM-IV borderline personality disorder // Journal of Clinical Psychiatry. – 2008. – Vol. 69, № 4. – P. 533–545.

19. Greendale, G. A., Huang M. H., Wight R. G. et al. Effects of the menopause transition and hormone use on cognitive performance in midlife women // Neurology. – 2009. – Vol. 72, № 21. – P. 1850–1857.

20. Häfner, H. Gender differences in schizophrenia // Psychoneuroendocrinology. – 2003. – Vol. 28, Suppl. 2. – P. 17–54.

21. Halbreich, U., Kahn L. S. Atypical depression, somatic depression and anxious depression in women: are they genderpreferred phenotypes? // Journal of Affective Disorders. – 2007. – Vol. 102, № 1–3. – P. 245–258.

22. Hamann, S. Sex differences in the responses of the human amygdala // The Neuroscientist. – 2005. – Vol. 11, № 4. – P. 288–293.

23. Hankin, B. L., Abramson L. Y. Development of gender differences in depression: an elaborated cognitive vulnerabilitytransactional stress theory // Psychological Bulletin. – 2001. – Vol. 127, № 6. – P. 773–796.

24. Henderson, V. W., Brinton R. D. Menopause and mitochondria: windows into estrogen effects on Alzheimer’s disease risk and therapy // Progress in Brain Research. – 2010. – Vol. 182. – P. 77–96.

25. Hoek, H. W. Incidence, prevalence and mortality of anorexia nervosa and other eating disorders // Current Opinion in Psychiatry. – 2006. – Vol. 19, № 4. – P. 389–394.

26. Hudson, J. I., Hiripi E., Pope H. G. et al. The prevalence and correlates of eating disorders in the National Comorbidity Survey Replication // Biological Psychiatry. – 2007. – Vol. 61, № 3. – P. 348–358.

27. Judd, L. L., Kessler R. C., Paulus M. P. et al. Comorbidity as a fundamental feature of generalized anxiety disorders // Acta Psychiatrica Scandinavica. – 1998. – Vol. 98, Suppl. 393. – P. 6–11.

28. Kaye, W. H., Fudge J. L., Paulus M. New insights into symptoms and neurocircuit function of anorexia nervosa // Nature Reviews Neuroscience. – 2009. – Vol. 10, № 8. – P. 573–584.

29. Kessler, R. C., Berglund P., Demler O. et al. Lifetime prevalence and age-of-onset distributions of DSM-IV disorders in the National Comorbidity Survey Replication // Archives of General Psychiatry. – 2005. – Vol. 62, № 6. – P. 593–602.

30. Kessler, R. C., Sonnega A., Bromet E. et al. Posttraumatic stress disorder in the National Comorbidity Survey // Archives of General Psychiatry. – 1995. – Vol. 52, № 12. – P. 1048–1060.

31. Kudielka, B. M., Kirschbaum C. Sex differences in HPA axis responses to stress: a review // Biological Psychology. – 2005. – Vol. 69, № 1. – P. 113–132.

32. Leadbeater, B. J., Kuperminc G. P., Blatt S. J. et al. A multivariate model of gender differences in adolescents’ internalizing and externalizing problems // Developmental Psychology. – 1999. – Vol. 35, № 5. – P. 1268–1282.

33. McEwen, B. S. Estrogen actions throughout the brain // Recent Progress in Hormone Research. – 2002. – Vol. 57. – P. 357–384.

34. Milad, M. R., Pitman R. K., Ellis C. B. et al. Neurobiological basis of failure to recall extinction memory in posttraumatic stress disorder // Biological Psychiatry. – 2010. – Vol. 66, № 12. – P. 1075–1082.

35. Murray, L., Arteche A., Fearon P. et al. Maternal postnatal depression and the development of depression in offspring up to 16 years of age // Journal of the American Academy of Child and Adolescent Psychiatry. – 2010. – Vol. 50, № 5. – P. 460–470.

36. Nolen-Hoeksema, S., Wisco B. E., Lyubomirsky S. Rethinking rumination // Perspectives on Psychological Science. – 2008. – Vol. 3, № 5. – P. 400–424.

37. Pigott, T. A. Gender differences in the epidemiology and treatment of anxiety disorders // Journal of Clinical Psychiatry. – 1999. – Vol. 60, Suppl. 18. – P. 4–15.

38. Sansone, R. A., Sansone L. A. Gender patterns in borderline personality disorder // Innovations in Clinical Neuroscience. – 2011. – Vol. 8, № 5. – P. 16–20.

39. Seedat, S., Scott K. M., Angermeyer M. C. et al. Crossnational associations between gender and mental disorders in the WHO World Mental Health Surveys // Archives of General Psychiatry. – 2009. – Vol. 66, № 7. – P. 785–795.

40. Seeman, M. V. Gender differences in the prescribing of antipsychotic drugs // American Journal of Psychiatry. – 2004. – Vol. 161, № 8. – P. 1324–1333.

41. Sit, D., Rothschild A. J., Wisner K. L. A review of postpartum psychosis // Journal of Women’s Health. – 2006. – Vol. 15, № 4. – P. 352–368.

42. Soares, C. N. Depression during the menopausal transition: window of vulnerability or continuum of risk? // Menopause. – 2013. – Vol. 21, № 2. – P. 198–200.

43. Stewart, D. E., Rondon M., Damiani G. et al. International psychosocial and systemic issues in women’s mental health // Archives of Women’s Mental Health. – 2004. – Vol. 6, № 1. – P. 13–17.

44. Sullivan, P. F. Mortality in anorexia nervosa // American Journal of Psychiatry. – 1995. – Vol. 152, № 7. – P. 1073–1074.

45. Suppes, T., Leverich G. S., Keck P. E. et al. The Stanley Foundation Bipolar Treatment Outcome Network. II. Demographics and illness characteristics of the first 261 patients // Journal of Affective Disorders. – 2005. – Vol. 67, № 1–3. – P. 45–59.

46. Tolin, D. F., Foa E. B. Sex differences in trauma and posttraumatic stress disorder: a quantitative review of 25 years of research // Psychological Bulletin. – 2006. – Vol. 132, № 6. – P. 959–992.

47. Turk, C. L., Heimberg R. G., Orsillo S. M. et al. An investigation of gender differences in social phobia // Journal of Anxiety Disorders. – 1998. – Vol. 12, № 3. – P. 209–223.

48. Viguera, A. C., Whitfield T., Baldessarini R. J. et al. Risk of recurrence in women with bipolar disorder during pregnancy // American Journal of Psychiatry. – 2007. – Vol. 164, № 12. – P. 1817–1824.

49. Widiger, T. A., Anderson K. G. Personality and depression in women // Journal of Affective Disorders. – 2003. – Vol. 74, № 1. – P. 59–66.

50. World Health Organization. Depression and Other Common Mental Disorders: Global Health Estimates. – Geneva: WHO, 2017. – 24 p.