Clinical and pathogenetic features moderate preeclampsia

The article presents the results of a multicenter open comparative controlled cohort study, which included 120 pregnant women with moderate preeclampsia and 40 pregnant women with a physiological pregnancy who were treated and delivered by cesarean section in “5th City Clinical Hospital”, “6th City Clinical Hospital” in Minsk for the period 2010–2024. The aim of the study was to study the clinical and pathogenetic features of pregnancy with moderate preeclampsia. The results were obtained: preeclampsia in pregnant women leads to an increase not only in weight gain (p = 0.0123), but also in hospital stay (p = 0.0000), according to ultrasound data, disorders such as fetoplacental blood flow disorders were more common (I–III) and fetal growth retardation, a combination of pathology (p = 0.0142), as well as a a decrease in the average concentration of hemoglobin in red blood cells (MCH) of 29.1 [24.1; 35.8] pg was detected, while the average volume of red blood cells (MCV) was 87 [75.5; 142.2] fl), an increase in cortisol to 1021.23 [927.85; 1205.30] ng/ml (p = 0.0128) and the severity of endogenous intoxication as in the mother (the MWM was statistically 80.7 % higher than compared with a physiologically occurring pregnancy and amounted to 0.47 [0.46; 0.55] conl. opt. pl., p = 0.0146, and in a newborn (the MWM in umbilical cord blood was significantly higher by 100 % compared with a physiologically occurring pregnancy and amounted to 0.46 [0.46; 0.52] conl. opt. pl., p = 0.0231). A glycemic level of more than 4.31 mmol/l (AUC = 0.689, p < 0.01, Sensitivity 84.6, Specificity 50.0) was determined as a predictor of the development of preeclampsia.

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