Characteristics of sepsis in children depending on etiology
https://doi.org/10.51922/1818-426X.2026.1.90
Abstract
Sepsis is a serious global problem, resulting in significant healthcare costs. The World Health Organization recognizes sepsis as a priority.
The aim of this study was to identify predictors of sepsis caused by gram-positive and gram-negative bacteria based on a comparative analysis of clinical manifestations and laboratory parameters.
Materials. A retrospective analysis of clinical data and laboratory parameters was conducted for 96 patients with sepsis treated at the Minsk City Children's Infectious Diseases Clinical Hospital from 2009 to 2023. To conduct a comparative analysis, patients were divided into groups based on the pathogen: Group 1 – 53 patients with sepsis caused by gram-positive bacteria, and Group 2–43 patients with sepsis caused by gram-negative bacteria.
Results. Septic shock developed in approximately half of the patients in both groups (47.2 % and 58.1 %, respectively), the median time from the onset of the first symptoms to the development of sepsis was 4 days (2–5) in Group 1 and 8 days (3–28) in Group 2 (p < 0.01), organ failure assessment using the Pelod, pSofa, Phoenix, and Prism scales revealed a trend toward higher scores in Group 2 (sepsis caused by Gram-negative bacteria).
Conclusion. According to the analysis, it was established that patients in Group 2 had a more severe course (according to clinical and laboratory data) and more often an unfavorable outcome.
References
1. Surviving sepsis campaign international guidelines for the management of septic shock and sepsis-associated organ dysfunction in children / S. L. Weiss [et al.] // Pediatric Crit Care Med. – 2020. – Vol. 21(2). – P. e52–e106. – doi: 10.1097/PCC.0000000000002198.
2. The global burden of pediatric and neonatal sepsis: a systematic review / C. Fleischmann-Struzek [et al.] // Lancet Respir Med. – 2018. – Vol. 6(3). – P. 223–230. – doi: 10.1016/S2213-2600(18)30063-8.
3. Epidemiology of blood culture-proven bacterial sepsis in children in Switzerland: a population-based cohort study / P. K. Agyeman [et al.] // The Lancet Child & Adolescent Health. – 2017. – Vol. 1(2). – P. 124–33.
4. Global, regional, and national sepsis incidence and mortality, 1990–2017: analysis for the Global burden of disease study / K. E. Rudd [et al.] // Lancet. – 2020. – Vol. 395(10219). – P. 200–211. – doi: 10.1016/S01406736(19)32989-7.
5. Pediatric sepsis definition taskforce. The current and future state of pediatric sepsis definitions: an international survey / L. Morin [et al.] // Pediatrics. – 2022. – Vol. 149(6). – P. e2021052565. – doi: 10.1542/peds.2021052565.
6. Pediatric sepsis definition-a systematic review protocol by the pediatric sepsis definition taskforce / K. Menon [et al.] // Crit Care Explor. – 2020. – Vol. 2(6). – P. e0123. – doi: 10.1097/CCE.0000000000000123.
7. Refractory septic shock in children: a European society of pediatric and neonatal intensive care definition / Morin L. [et al.] // Intensive Care Med. – 2016. – Vol. 42(12). – P. 1948–1957. – doi: 10.1007/s00134-016-4574-2.
8. Prognostic differences in sepsis caused by gramnegative bacteria and gram-positive bacteria: a systematic review and meta-analysis / A. Tang [et al.] // Crit Care. – 2023. – Vol. 27(1). – P. 467. – doi: org/10.1186/s13054023-04750-w.
9. The relationship between serum levels of procalcitonin, endotoxin and C-reactive protein and pathogenic bacteria and prognosis in sepsis patients / B. Wu [et al.] // Chin J Blood Purif. – 2022. – Vol. 21(06). – P. 432–435.
10. Procalcitonin and C-reactive protein in early diagnosis of sepsis caused by either gram-negative or grampositive bacteria / H. H. Liu [et al.] // Ir J Med Sci. – 2017. – Vol. 186(1). – P. 207–212.
11. Gram-negative bacterial infection causes aggravated innate immune response in sepsis: studies from clinical samples and cellular models / C. Duan [et al.] // Biochem Biophys Res Commun. – 2023. – Vol. 650. – P. 137–144.
Review
For citations:
Serhiyenka K.N. Characteristics of sepsis in children depending on etiology. Medical Journal. 2026;(1):90-95. (In Russ.) https://doi.org/10.51922/1818-426X.2026.1.90
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