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Venous thromboembolic complications in pregnant women

https://doi.org/10.51922/1818-426X.2025.2.77

Abstract

Materials and methods. We conducted a retrospective analysis of 63 medical records of pregnant women with thrombophlebitis and phlebothrombosis of the lower extremities.

Results and discussion. In 41 cases pregnant women had thrombophlebitis of the superficial veins of the lower extremities and in 22 cases – phlebothrombosis of the deep veins. Thrombophlebitis of the superficial veins in 100 % cases developed on the background of varicose disease of the lower extremities. Pulmonary embolism developed in 2 out of 41 patients with thrombophlebitis of the superficial veins (3.2 %) and in 3 out of 22 patients with deep vein thrombosis (13.7 %). We conducted surgical treatment in 7 patients. In 6 cases we performed crossectomy, in one case – ligation of superficial femoral vein. There is a tendency for higher incidence of pulmonary embolism in deep vein thrombosis compared to superficial thrombophlebitis (13.7 and 3.2 %, respectively). However, there are no statistically significant differences, which, in our opinion, is due to the size of the group.

Conclusions. 1. Superficial vein thrombophlebitis in all patients developed on the background of varicose disease. This indicates the need for varicose disease correction as pregravid preparation. 2. There is a tendency towards a higher incidence of pulmonary embolism in deep vein phlebothrombosis compared to thrombophlebitis of superficial veins in pregnant women.

About the Authors

P. P. Koshevskyм
УО «Белорусский государственный медицинский университет»
Belarus


S. A. Alekseev
УО «Белорусский государственный медицинский университет»
Belarus


N. N. Chizhik
УЗ «Минский клинический консультативно-диагностический центр»
Belarus


A. A. Bezvoditskaya
УО «Белорусский государственный медицинский университет»
Belarus


V. A. Ginyuk
УО «Белорусский государственный медицинский университет»
Belarus


N. N. Dorokh
УО «Белорусский государственный медицинский университет»
Belarus


O. V. Popkov
УО «Белорусский государственный медицинский университет»
Belarus


References

1. Andriyashkin, V. V., Dzhenina O. V., Bychkova T. V., Leont’ev S. G., Zolotuhin I. A., Kirienko A. I. Hirurgicheskaya taktika u beremennyh s trombozami glubokih ven nizhnih konechnostej // Flebologiya. – 2010. – Vol. 4, № 3. – Р. 62–66.

2. Enrique, Reyes Muñoz, Nayeli Martínez Huerta, Francisco Ibargüengoitia Ochoa, Samuel Vargas Trujillo, Víctor Vidal González. Treatment to pregnant women with deep venous thrombosis experience at Instituto Nacional de Perinatología // Ginecol Obstet Mex. – 2008. – Vol. 76, № 5. – P. 249–255 (in Spanish). Available at: https://pubmed.ncbi.nlm.nih.gov/18798428/ (Accessed 14 September 2025).

3. Susana, Collado Peña, Luis Alberto Villanueva. Current concepts of venous thromboembolism and anticoagulation during pregnancy // Ginecol Obstet Mex. – 2004. – № 72. – P. 150–161 (in Spanish). Available at: https://pubmed.ncbi.nlm.nih.gov/15318755/ (Accessed 14 September 2025).

4. Andra, H. James. Venous thromboembolism in pregnancy // Review Arterioscler Thromb Vasc Biol. – 2009. – Vol. 29, № 3. – P. 326–331. doi: 10.1161/ATVBAHA.109.184127.

5. Andra, H. James, Victor F. Tapson, Samuel Z. Goldhaber. Thrombosis during pregnancy and the postpartum period // Am J Obstet Gynecol. – 2005. – Vol. 193, № 1. – P. 216–219. doi: 10.1016/j.ajog.2004.11.037.

6. Angeles, Blanco-Molina, Javier Trujillo-Santos, Juan Criado, Luciano Lopez, Ramón Lecumberri, Reyes Gutierrez, Manuel Monreal. Venous thromboembolism during pregnancy or postpartum: findings from the RIETE Registry // Comparative Study Thromb Haemost. – 2007. – Vol. 97, № 2. – P. 186–190. Available at: https://pubmed.ncbi.nlm.nih.gov/17264945/ (Accessed 14 September 2025).

7. Shannon, M. Bates, Ian A. Greer, Ingrid Pabinger, Shoshanna Sofaer, Jack Hirsh. Venous thromboembolism, thrombophilia, antithrombotic therapy, and pregnancy: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) // Practice Guideline Chest. – 2008. – Vol. 133, № 6. – P. 844–886. doi: 10.1378/chest.08-0761.

8. Shannon, M. Bates, Ian A. Greer, Saskia Middeldorp, David L. Veenstra, Anne-Marie Prabulo, Per Olav Vandvik. VTE, thrombophilia, antithrombotic therapy, and pregnancy: Antithrombotic Therapy and Prevention of Thrombosis, 9th ed: American College of Chest Physicians EvidenceBased Clinical Practice Guidelines // Practice Guideline Chest. – 2012. – Vol. 141, № 2. – P. 691–736. doi: 10.1378/chest.11-2300

9. Zhonghua, Fu Chan, Ke Za Zhi. Clinical analysis of 20 pregnant women with venous thromboembolic disease // Zhonghua Fu Chan KeZaZhi. – 2011. – Vol. 46, № 12. – P. 911–916 (in Chinese). Available at: https://pubmed.ncbi.nlm.nih.gov/22333281/ (Accessed 14 September 2025).

10. Delgado, García D. R., Real Valdés R., Serrano Rodríguez M. L., Molina Mendoza C. R., Quílez Caballero E., García Del Valle Manzano S. Massive deep vein thrombosis in pregnant women: The importance of individualizing the action plan // Rev EspAnestesiolReanim (Engl Ed). – 2022. – Vol. 69, № 8. – P. 497–501. doi: 10.1016/j.redare.2021.07.005.


Review

For citations:


Koshevskyм P.P., Alekseev S.A., Chizhik N.N., Bezvoditskaya A.A., Ginyuk V.A., Dorokh N.N., Popkov O.V. Venous thromboembolic complications in pregnant women. Medical Journal. 2025;(2):77-81. (In Russ.) https://doi.org/10.51922/1818-426X.2025.2.77

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ISSN 1818-426X (Print)