Toxicological characteristics, hazard classification and substantiation of maximum permissible concentrations of the pharmaceutical substance of metformin hydrochloride in the air of the working area and atmosphere
https://doi.org/10.51922/1818-426X.2022.4.39
Abstract
A toxicological and hygienic assessment of the pharmaceutical substance of metformin hydrochloride was performed using various regimens, doses and ways of entry into the body of laboratory animals. The conducted studies allowed us to establish the parameters of the toxicometry of metformin and the features of its biological action, which consist in the absence of an irritating effect on the skin and skin-resorptive properties, an allergenic effect on the body and weak cumulative properties and irritant effect on the mucous membranes of the eyes. Hazard classes of the metformin hydrochloride and hygienic regulations for this substance content in the air of the working area and atmosphere have been developed.
About the Authors
E. K. Vlasenko
Научно-практический центр ЛОТИОС
Belarus
Belarus
V. N. Gapanovich
Научно-практический центр ЛОТИОС
Belarus
Belarus
E. N. Vasilyeva
Научно-практический центр ЛОТИОС
Belarus
Belarus
E. L. Berdina
Научно-практический центр ЛОТИОС
Belarus
Belarus
S. V. Andreev
Научно-практический центр ЛОТИОС
Belarus
Belarus
O. M. Klimovich
Научно-практический центр ЛОТИОС
Belarus
Belarus
A. N. Eliseenko
Научно-практический центр ЛОТИОС
Belarus
Belarus
M. A. Bartosh
Научно-практический центр ЛОТИОС
Belarus
Belarus
E. A. Kozlova
Научно-практический центр ЛОТИОС
Belarus
Belarus
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Review
For citations:
Vlasenko E.K., Gapanovich V.N., Vasilyeva E.N., Berdina E.L., Andreev S.V., Klimovich O.M., Eliseenko A.N., Bartosh M.A., Kozlova E.A. Toxicological characteristics, hazard classification and substantiation of maximum permissible concentrations of the pharmaceutical substance of metformin hydrochloride in the air of the working area and atmosphere. Medical Journal. 2022;(4):39-46. (In Russ.) https://doi.org/10.51922/1818-426X.2022.4.39
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