THE ROLE OF FOLATE CYCLE GENE POLYMORPHISMS IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND TYPE 2 DIABETES MELLITUS
https://doi.org/10.51922/1818-426X.2024.1.33
Abstract
Cardiovascular diseases are still the leading causes of death in the world. Atherosclerosis of the arteries of the lower extremities is one of them. A risk factor for the development of atherosclerosis is diabetes mellitus, particularly type 2. The fact that these diseases are systemic and multifactorial is generally recognized. Considering the progress of genetics and gene therapy in recent decades, the search for genes responsible for the development of both lower limb atherosclerosis and type 2 diabetes mellitus is relevant. Their identification can probably help to improve the prognosis of the course of these diseases, personalize the system of prevention and treatment. Homocysteine is an amino acid involved in the pathogenesis of both obliterative atherosclerosis and diabetes mellitus. In this context, folate cycle genes, which play a major role in the development of hyperhomocysteinemia, are of particular interest.
About the Authors
A. R. Obuhovich
УО «Гродненский государственный медицинский университет»
Russian Federation
Russian Federation
N. N. Ioskevich
УО «Гродненский государственный медицинский университет»
Russian Federation
Russian Federation
V. P. Vasilevskij
УО «Гродненский государственный медицинский университет»
Russian Federation
Russian Federation
V. A. Dajnovich
УЗ «Гродненская университетская клиника»
Russian Federation
Russian Federation
References
1. Elykomov, V. A. Tromboticheskie sobytija i sostojanie tromboticheskoj gotovnosti u pacientov s ishemicheskoj bolezn’ju serdca / V. A. Elykomov, E. A. Nomokonova, A. A. Efremushkina // Bjulleten’ medicinskoj nauki. – 2018. – № 3 (11). – S. 53–57.
2. Levashova, O. A. Analiz urovnja gomocisteina i rasprostranennost’ geneticheskogo polimorfizma genov folatnogo cikla u bol’nyh ishemicheskim insul’tom / O. A. Levashova, I. G. Zolkornjaev // Zdorov’e i obrazovanie v XXI v. – 2017. – T. 19, № 1. – S. 97–99.
3. Obuhovich, A. R. Vlijanie polimorfizmov genov folatnogo cikla na ishody hirurgicheskogo lechenija ateroskleroticheskogo porazhenija arterij nizhnih konechnostej / A. R. Obuhovich, N. N. Ioskevich, S. V. Zhdonec // Hirurgija Belarusi – sostojanie i razvitie: sb. materialov nauch.-prakt. konf. s mezhdunar. uchastiem i XVII Sezda hirurgov Respubliki Belarus, Mogilev, 12–13 okt. 2023 g. / pod red. G. G. Kondratenko, O. O. Rummo, A. I. Protasevicha. – Minsk, 2023. – S. 355–357.
4. Polimorfizm genov folatnogo cikla kak faktor riska formirovanija gipergomocisteinemii / A. M. Ivanov [et al.] // Analiz riska zdorovju. – 2020. – № 4. – S. 137–146. – doi: 10.21668/health.risk/2020.4.16.
5. Rol’ polimorfizmov genov folatnogo cikla v razvitii perifericheskogo ateroskleroza v jetnicheskih gruppah Respubliki Adygeja / I. V. Smol’kov [et al.] // Vestnik AGU. – 2017. – № 1 (196). – S. 72–80.
6. Uroven’ gomocisteina i polimorfizmy genov folatnogo obmena u pacientov s ishemicheskoj bolezn’ju serdca i saharnym diabetom 2 tipa / Je. V. Davydchik [et al.] // Neotlozhnaja kardiologija i kardiovaskuljarnye riski. – 2019. – T. 3, № 2. – S. 690–695.
7. Cyganenko, O. V. Klinicheskie osobennosti ishemicheskih insul’tov v molodom vozraste pri no sitel’stve polimorfizma metionin-sintazy-reduktazy A66G / O. V. Cyganenko, L. I. Volkova, A. M. Alasheev // Nevrologija, nejropsihiatrija, psihosomatika. – 2021. – № 13 (4). – S. 25–29. – doi: 10.14412/2074-2711-2021-4-25-29.
8. Shih, E. V. Polimorfizmy genov fermentov folatnogo cikla: rasprostranennost’, vzaimosvjaz’ s urovnem gomocisteina, folievoj kisloty i vitamina B 12 plazmy krovi / E. V. Shih, A. V. Putinceva // Akusherstvo i ginekologija. – 2022. – № 3. – S. 104–111. – doi: 10.18565/aig.2022.3.104-111.
9. Association between polymorphism of methylenetetrahydrofolate reductase (MTHFR) C677T and risk of myocardial infarction: a meta-analysis for 8,140 cases and 10,522 controls / С. Xuan [et al.] // Archives of Medical Research. – 2011. – Vol. 42, № 8. – Р. 677–685. – doi: 10.1016/j.arcmed.2011.11.009.
10. Association of MTHFR C677T polymorphism with insulin resistance, results of NURSE Study (Nursing Unadequainted Related Stress Etiologies) / M. Kheradmand [et al.] // J Diabetes Metab Disord. – 2017. – Vol. 16. – P. 22. – doi: 10.1186/s40200-017-0303-9. eCollection 2017.
11. Association of two methylentetrahydrofolate reductase polymorphisms (rs1801133, rs1801131) with the risk of type 2 diabetes in south-east of Iran / M. Pooduneh [et al.] // Rep Biochem Mol Biol. – 2019. – Vol. 8, № 2. – P. 178–183.
12. Associations between serum betaine, methyl-metabolizing genetic polymorphisms and risk of incident type 2 diabetes: a prospective cohort study in community-dwelling Chinese adults / X. Lu [et al.] // Nutrients. – 2022. – Vol. 14, № 2. – P. 362. – doi: 10.3390/nu14020362.
13. Cardiovascular Outcomes After Lower Extre mity Endovascular or Surgical Revascularization: The EUCLID Trial / I. Baumgartner [et al.] // Journal of the American Colledge of Cardiology. – 2018. – Vol. 2, № 72 (14). – P. 1563–1572. – doi: 10.1016/j.jacc.2018.07.046.
14. Effect of MHHFR A1298C and MTRR A66G genetic mutations on homocysteine levels in the Chinese population: a systematic review and meta-analysis / J. Wang [et al.] // Journal of translational internal medicine. – 2017. – Vol. 5, № 4. – P. 220–229.
15. Factors influencing the risk of major amputation in patients with diabetic foot ulcers treated by autologous cell therapy / J. Husakova [et al.] // J Diabetes Res. – 2022. – Vol. 2022. – Р. 3954740. – doi: 10.1155/2022/3954740. eCollection 2022. ID 3954740.
16. Genetic Polymorphisms and the Risk of Myocardial Infarction in Patients Under 45 Years of Age / A. Sakowicz [et al.] // Biochemical Genetics. – 2013. – Vol. 51. – P. 230–242. – doi: 10.1007/s10528-012-9558-5.
17. Nutritional and medical food therapies for diabetic retinopathy / C. Shi [et al.] // Eye and vision. – 2020. – Vol. 7. – Р. 33. – doi: 10.1186/s40662-020-00199-y. eCollection 2020.
18. Raghubeer, S. Methylentetrahydrofolate (MTHFR), the one-carbon cycle, and cardiovascular risks / S. Raghubeer, T. E. Matsha // Nutrients. – 2021. – Vol. 13, № 12. – Р. 4562. – doi: 10.3390/nu13124562.
19. The MTHFR C677T polymorphism influen ces the efficacy of folic acid supplementation on the nerve conduction studies in patients with diabetic polyneuropathy; a randomized, double blind, placebo-controlled study / T. Mottaghi [et al.] // Journal of research in medical sciences. – 2019. – Vol. 24. – P. 36. – doi: 10.4103/jrms.JRMS_774_18. eCollection 2019.
20. The role of genetics in coronary artery bypass surgery patients under 30 years of age / S. Sarikaya [et al.] // Cardiovascular journal of Africa. – 2017. – Vol. 28, № 2. – P. 77–80. – doi: 10.5830/CVJA-2016-042.
Review
For citations:
Obuhovich A.R., Ioskevich N.N., Vasilevskij V.P., Dajnovich V.A. THE ROLE OF FOLATE CYCLE GENE POLYMORPHISMS IN THE DEVELOPMENT OF ATHEROSCLEROSIS AND TYPE 2 DIABETES MELLITUS. Medical Journal. 2024;(1):33-41. (In Russ.) https://doi.org/10.51922/1818-426X.2024.1.33
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