Evaluation of the efficacy of complex treatment of postpartum uterine subinvolution

The aim of the study was to study the clinical effectiveness of the complex treatment of postpartum subinvolution of the uterus with intrauterine dialysis of levofloxacin solution by assessing the correlation between the size of the uterine cavity, the level of norepinephrine and cholinesterase in the blood serum of puerperas. We examined 35 puerperas with SCI (mean age 26.1 ± 2.2) who were in the physiological postpartum department of the ME “3rd City Clinical Hospital named after E. V. Klumova, Minsk. The control group consisted of 19 puerperas with a physiological postpartum period (mean age 24.5 ± 2.1). The main group included 17 patients who received drug therapy in accordance with the treat- ment protocol in combination with intrauterine dialysis of a solution of levofloxacin in a volume of 20 ml, diluted in 20 ml of chlorhexidine solvent, using a syringe into the uterine cavity bolus 1 time per day for 3–5 days. In addition, AMF procedures were prescribed for the lower abdomen in the area of the projection of the uterus from the 1st day after childbirth every day 1 time per day. The comparison group consisted of 18 patients who received only drug treatment (intramuscular injection of a solution of oxytocin at 5 IU after 12 hours, intravenous administration of a solution of cefotaxime intravenously at a dose of 1 g after 8 hours) for 5 days.The results obtained convincingly demonstrate a decrease in the level of norepinephrine and an increase in the activity of cholinesterase in the blood serum of puerperas with the development of postpartum subinvolution of the uterus, which is associated with an increase in the size of the uterine cavity.

1. Veres, I. A. Analiz klinicheskih proyavlenij poslerodovoj subinvolyucii matki kak predstadii gipotonicheskogo poslerodovogo endometrita / I. A. Veres // Ros. vestn. akushera-ginekologa. – 2020. – Vol. 20, № 5. – S. 84–90.

2. Veres, I. A. Primenenie peremennogo magnitnogo polya dlya profilaktiki poslerodovogo endometrita / I. A. Veres, O. A. Peresada, N. S. Savateeva, I. M. Gologutskaya // Med. zhurn. – 2017. – № 2. – S. 68–73.

3. Polozhitel’noe reshenie o vydache patenta na izobretenie RB po zayavke № a 20210092 ot 24.12.2021 g. «Sredstvo dlya lecheniya akusherskoj rany, oslozhnennoj gipotoniej matki»; avtory: I. A. Veres, V. P. Sokol.

4. Tirskaya, Yu. I. Profilaktika poslerodovogo endometrita u rodil’nic s razlichnoj stepen’yu infekcionnogo riska s primeneniem applikacionnoj formy sorbenta / Yu. I. Tirskaya [et al.] // Ros. med. zhurn. – 2015. – № 3. – S. 36–42.