COMMON CHARACTERISTICS OF IMMUNE AND HEMATOLOGIC PARAMETERS IN EXPERIMENTAL ACUTE RESPIRATORY DISTRESS SYNDROME

Acute respiratory distress syndrome is one of the most current problems in modern medicine. Being an outcome of many different pathologies, ARDS affects patients of various ages, occupations, anamnesis and risk groups. The status of the most popular cause of ARDS manifestation is given to sepsis or septic shock, which are followed by generalized bacterial infections and bacterial pneumonia. This research displays the effect of bacterial lipopolysaccharide intrapulmonary admission in lab animals, hemostatic disorders in experimental ARDS, role of ribonucleases in respiratory tract pathology and the interconnection in between immune, hemostatic and enzymatic branches of homeostasis regulation. Increased expression of eosinophilic ribonucleases in lung tissue showed the connection between experimental ARDS and RNAse local activity. Serum ribonuclease activity showed a response to the release of proinflammatory cytokines aimed at correcting, among other things, hemostatic disorders. Thus, tissue ribonuclease expression and serum ribonuclease levels can serve as a criterion for assessing the intensity of immune responses in the context of respiratory diseases and also provide a rationale for the use of RNase-containing drugs for immunomodulation and the prevention of coagulation disorders.

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