DYNAMICS OF COMPLETE BLOOD TEST AND C-REACTIVE PROTEIN VALUES IN PATIENTS WITH COPD AND VARIOUS SEVERITIES OF OBSTRUCTIVE CHANGES IN THE LUNG
https://doi.org/10.51922/1818-426X.2026.3.105
Abstract
This study aims to determine the dynamics of complete blood count (CBC) and C-reactive protein (CRP) levels in patients with COPD varying degrees of obstructive pulmonary changes during an exacerbation, treatment, and in stable period.
61 patients with COPD and 27 individuals without signs of pathology were examined. Patients were examined before the start of inpatient treatment and after 14 and 90 days. Cell count and ESR were determined in venous blood samples, and CRP levels were measured in serum. The results were analyzed using nonparametric descriptive statistics.
Regardless of the severity of obstructive pulmonary changes, signs of systemic inflammation were present in the blood of patients with COPD before treatment. This was manifested by an increase in leukocyte count, the concentration and relative number of neutrophils, and, in cases of severe obstruction, an increase in lymphocytes and monocytes, ESR, and CRP compared to control values. After 14 days, contrary to the expected decrease during therapy, these indicators continued to increase or remained high. After 90 days, levels of leukocytes, neutrophils, monocytes, and CRP had significantly decreased compared to the peak after 14 days, approaching baseline values (before treatment), but still exceeded normal.
These observed changes are characteristic of chronic, poorly controlled systemic inflammation, which is a key factor determining disease progression and the risk of adverse outcomes.
About the Authors
A. D. Taganovich
Belarusian State Medical University
Belarus
Belarus
Minsk
N. N. Kovganko
Belarusian State Medical University
Belarus
Belarus
Minsk
I. A. Nikitina
Belarusian State Medical University
Belarus
Belarus
Minsk
T. V. Ryabtseva
Belarusian State Medical University
Belarus
Belarus
Minsk
E. I. Davidovskaya
Republican Scientific and Practical Center of Pulmonology and Phthisiology
Belarus
Belarus
Minsk
L. S. Bogush
Republican Scientific and Practical Center of Pulmonology and Phthisiology
Belarus
Belarus
Minsk
O. A. Budnik
Republican Scientific and Practical Center of Pulmonology and Phthisiology
Belarus
Belarus
Minsk
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Review
For citations:
Taganovich A.D., Kovganko N.N., Nikitina I.A., Ryabtseva T.V., Davidovskaya E.I., Bogush L.S., Budnik O.A. DYNAMICS OF COMPLETE BLOOD TEST AND C-REACTIVE PROTEIN VALUES IN PATIENTS WITH COPD AND VARIOUS SEVERITIES OF OBSTRUCTIVE CHANGES IN THE LUNG. Medical Journal. 2026;(3):105-111. (In Russ.) https://doi.org/10.51922/1818-426X.2026.3.105
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