Hybrid material based on fibrin and hydroxyapatite gel for experimental septoplasty
https://doi.org/10.51922/1818-426X.2023.4.14
Abstract
Experimental work was carried out using a hybrid material based on fibrin and hydroxyapatite gel for use in septoplasty. On the model of the pig’s head, the technology was worked out with the reimplantation of a part of the nasal septum with a hybrid material containing small fragments of cartilage. After separating the soft tissues of the nose, detaching the mucoperichondrium, a part of the porcine nasal septum 2ђ3 cm in size was resected and fragmented, which was used to form a hybrid material. The basis of the hybrid material was citrate plasma. To initiate the fibrin polymerization cascade, a mixture of solutions based on 10 % calcium gluconate and adrenaline (1.85 mg/ml) was used at a calcium gluconate/ adrenaline volume ratio of 17:1. Synthetic hydroxyapatite gel was used to stimulate osteoconduction and osteoinduction. From the above components, a hybrid material was formed, which, upon repeated compression, was compacted due to fibrin retraction. The hybrid material was successfully installed in the area of the porcine nasal septal defect, which confirms the possibility of performing septoplasty using this technique.
About the Authors
R. A. Vlasov
ООО «ПримаМед Групп»
Belarus
Belarus
V. K. Krut’ko
ИОНХ НАН Беларуси
Belarus
Belarus
I. E. Glazov
ИОНХ НАН Беларуси
Belarus
Belarus
O. N. Musskaya
ИОНХ НАН Беларуси
Belarus
Belarus
E. V. Gnilyakevich
ООО МЦ «ЛОДЭ»
Belarus
Belarus
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Review
For citations:
Vlasov R.A., Krut’ko V.K., Glazov I.E., Musskaya O.N., Gnilyakevich E.V. Hybrid material based on fibrin and hydroxyapatite gel for experimental septoplasty. Medical Journal. 2023;(4):14-21. (In Russ.) https://doi.org/10.51922/1818-426X.2023.4.14
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