INDICATORS OF PROOXIDANT – ANTIOXIDANT STATUS IN THE STOMACH WALL DURING SEAMLESS CLOSURE OF A PERFORATIVE HOLE IN AN EXPERIMENT
https://doi.org/10.51922/1818-426X.2025.4.82
Abstract
Introduction. Surgical treatment of perforated ulcer is an additional factor in traumatization of local tissues of the stomach, which can contribute to the development of postoperative complications.
Purpose of the study. To evaluate the indicators of prooxidant-antioxidant status in the wall of the stomach with a sutureless method of closing a perforated ulcer opening.
Materials and methods. The level of prooxidants and antioxidants in gastric tissue samples of laboratory animals was studied after seamless closure of the perforation hole in comparison with traditional suture closure.
Results and conclusion. It is shown that during seamless sealing of the gastric perforation using fibrin glue “Fibrinostat” the same processes occur as during suture sealing, however, oxidative stress is less pronounced, which may be associated with the antioxidant, gastroprotective and regenerative properties of fibrin glue.
About the Authors
E. I. Makarevich
Educational Institution “Grodno State Medical University”
Belarus
Belarus
V. V. Kudlo
Educational Institution “Grodno State Medical University”
Belarus
Belarus
I. G. Zhuk
Educational Institution “Grodno State Medical University”
Belarus
Belarus
I. E. Gulyai
Educational Institution “Grodno State Medical University”
Belarus
Belarus
V. A. Gornak
Educational Institution “Grodno State Medical University”
Belarus
Belarus
E. A. Latutina
Educational Institution “Grodno State Medical University”
Belarus
Belarus
D. F. Yakimovich
Healthcare Institution “Grodno University Clinic”
Belarus
Belarus
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Review
For citations:
Makarevich E.I., Kudlo V.V., Zhuk I.G., Gulyai I.E., Gornak V.A., Latutina E.A., Yakimovich D.F. INDICATORS OF PROOXIDANT – ANTIOXIDANT STATUS IN THE STOMACH WALL DURING SEAMLESS CLOSURE OF A PERFORATIVE HOLE IN AN EXPERIMENT. Medical Journal. 2025;(4):82-87. (In Russ.) https://doi.org/10.51922/1818-426X.2025.4.82
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