Markers of implantation susceptibility in endometrial hypoplasia
https://doi.org/10.51922/1818-426X.2022.3.132
Abstract
To date, markers of endometrial implantation susceptibility in patients with endometrial hypoplasia have not been sufficiently studied. 59 patients with endometrial hypoplasia were examined, in whom treatment in accordance with clinical protocols (hormonal and/or in vitro fertilization) did not yield results (the main group), 16 women with endometrial hypoplasia who became pregnant after standard therapy (comparison group), and 23 somatically healthy fertile women (control group). There were no age differences in the groups.The analysis of clinical and anamnestic data was carried out, threedimensional ultrasound and immunohistochemical studies of the endometrium were performed. It is shown that the main markers of implantation susceptibility in endometrial hypoplasia are the presence of unsuccessful attempts of in vitro fertilization in the anamnesis, the uniformity and presence of a threelayer structure of the endometrium, the volume of the endometrium and the cellular density of the endometrial stroma. Immunohistochemical markers of implantation susceptibility in endometrial hypoplasia are the expression of receptors for estrogens html5-dom-document-internal-entity2-945-end in the endometrial stroma, integrin html5-dom-document-internal-entity2-945-endvhtml5-dom-document-internal-entity2-223-end3 – in the glandular layer of the endometrium, and the gene NOHA10 and the surface marker EMSC SUSD2 – both in the glandular tissue and in the endometrial stroma.
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Review
For citations:
Tsareva N.V. Markers of implantation susceptibility in endometrial hypoplasia. Medical Journal. 2022;(3):132-136. (In Russ.) https://doi.org/10.51922/1818-426X.2022.3.132
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