On the participation of liver arginase and kupffer cells in the regulation of cholesterol in the liver and blood lipoproteins, the level of iodine-containing thyroid hormones and body temperature in rats with experimental peritonitis
https://doi.org/10.51922/1818-426X.2023.1.132
Abstract
Despite the successes of modern surgery, the achievements of asepsis and antisepsis, the rather wide possibilities of antibacterial, infusion and detoxification therapy, the incidence of peritonitis and mortality from it remain at a high level. The aim of the study was to elucidate the significance of the activity of liver arginase and Kupffer cells in the regulation of total cholesterol in the liver and blood lipoproteins, the level of iodine-containing thyroid hormones and body temperature in rats with experimental peritonitis.
It has been established that under conditions of experimental peritonitis in rats, the activity of liver arginase decreases, the content of NO3–/NO2– increases and the level of iodine-containing thyroid hormones in the blood decreases, secondary atherogenic dyslipoproteinemia develops. A decrease in the activity of Kupffer cells in peritonitis is accompanied by an increase in the level of triiodothyronine in the blood, a less pronounced decrease in the activity of liver arginase and a weakening of the development of characteristic changes in the content of total cholesterol in the liver, lipoprotein cholesterol in the blood and prevents the development of secondary dyslipoproteinemia. Depression of liver arginase in conditions of peritonitis aggravates changes in the content of total cholesterol in blood and liver lipoproteins, triiodothyronine in the blood and contributes to the development of secondary dyslipoproteinemia.
About the Authors
E. N. Chepeleva
УА «Беларускі дзяржаўны медыцынскі ўніверсітэт»
Belarus
Belarus
F. I. Vismont
УА «Беларускі дзяржаўны медыцынскі ўніверсітэт»
Belarus
Belarus
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Review
For citations:
Chepeleva E.N., Vismont F.I. On the participation of liver arginase and kupffer cells in the regulation of cholesterol in the liver and blood lipoproteins, the level of iodine-containing thyroid hormones and body temperature in rats with experimental peritonitis. Medical Journal. 2023;(1):132-138. (In Russ.) https://doi.org/10.51922/1818-426X.2023.1.132
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