Prevalence of antibodies to the hepatitis E virus in the blood of belarusian donors
https://doi.org/10.51922/1818-426X.2022.4.53
Abstract
The number of reported cases of transmission of hepatitis E virus (HEV) through blood transfusion is constantly increasing, making it necessary to screen donations for HEV. The aim of this study was to identify markers of hepatitis E-immunoglobulins G and M, in the blood of Belarusian donors. The material for the study was blood serum samples obtained from 452 donors who donated blood in Minsk in the period from 2020 to 2022. IgM and IgG against HEV in blood serum were determined by enzyme immunoassay using diagnostic kits manufactured by NPO Diagnostic Systems and Vector-Best (RF). Anti-HEV IgG was found in 5.75 % of the samples, and anti-HEV IgM contained 1.77 % of the studied sera. In the ALT group of positive donors, anti-HEV IgG were detected in 6.8 % of cases and 2.27 % of sera contained anti-HEV IgM. There were no statistically significant differences in the seroprevalence of anti-HEI IgG and anti-HEI IgM depending on sex. Screening for HEV should be introduced into the system of infectious safety of donor blood in the Republic of Belarus. Immunocompromised patients and pregnant women should receive only HEV-negative donated blood products.
About the Authors
V. V. Davydov
Белорусский государственный медицинский университет
Belarus
Belarus
S. V. Zhavoronok
Белорусский государственный медицинский университет
Belarus
Belarus
I. S. Zadora
Белорусский государственный медицинский университет
Belarus
Belarus
L. V. Novak
Республиканский научно-практический центр трансфузиологии и медицинских биотехнологий
Belarus
Belarus
F. N. Karpenko
Республиканский научно-практический центр трансфузиологии и медицинских биотехнологий
Belarus
Belarus
O. V. Levandovskaya
Минский научно-практический центр хирургии, трансплантологии и гематологии
Belarus
Belarus
A. M. Kudryavceva
Белорусский государственный медицинский университет
Belarus
Belarus
References
1. Molecular and serological infection marker screening in blood donors indicates high endemicity of hepatitis E virus in Poland / P. Grabarczyk [et al.] // Transfusion. – 2018. – Vol. 58, № 5. – P. 1245–1253.
2. Risk factors for hepatitis E virus seropositivity in Dutch blood donors / S. H. Mooij [et al.] // BMC Infect Dis. – 2018. – T. 18, № 1. – S. 173.
3. Novel Approach for Detection of Hepatitis E Virus Infection in German Blood Donors / T. Vollmer [et al.] // J Clin Microbiol. – 2012. – T. 50, № 8. – S. 2708–2713.
4. High prevalence of anti-hepatitis E virus antibodies among blood donors in central Italy, February to March 2014 / C. Lucarelli [et al.] // Eurosurveillance. – 2016. – Vol. 21, № 30. – P. 30299.
5. Hepatitis E virus infection in the Irish blood donor population / J. O’Riordan [et al.] // Transfusion. – 2016. – Vol. 56, № 11. – P. 2868–2876.
6. Prevalence and 9-year incidence of hepatitis E virus infection among North Italian blood donors: Estimated transfusion risk / M. Spreafico [et al.] // Journal of Viral Hepatitis. – 2020. – Vol. 27, № 8. – P. 858–861.
7. Hepatitis E Virus Seroprevalence among Blood Donors in Southwest Switzerland / A. Kaufmann [et al.] // PLOS ONE. – 2011. – Vol. 6, № 6. – P. e21150.
8. Hepatitis E virus in Scottish blood donors / A. Cleland [et al.] // Vox Sanguinis. – 2013. – Vol. 105, № 4. – P. 283–289.
9. Hepatitis E virus in Spanish donors and the necessity for screening / A. Rivero-Juarez [et al.] // Journal of Viral Hepatitis. – 2019. – Vol. 26, № 5. – P. 603–608.
Review
For citations:
Davydov V.V., Zhavoronok S.V., Zadora I.S., Novak L.V., Karpenko F.N., Levandovskaya O.V., Kudryavceva A.M. Prevalence of antibodies to the hepatitis E virus in the blood of belarusian donors. Medical Journal. 2022;(4):53-59. (In Russ.) https://doi.org/10.51922/1818-426X.2022.4.53
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