Indicators of reticulocytes and erythrocytes in assessment of anemic syndrome in juvenile idiopathic arthritis
https://doi.org/10.51922/1818-426X.2023.2.104
Abstract
The article presents the results of a study of erythrocyte and reticulocyte indices in patients with juvenile idiopathic arthritis (JIA).
The aim of the study was the possibility of early diagnosis of anemic syndrome in patients with JIA based on the study of reticulocyte indices.
Materials and methods. 118 patients with JIA at the age of 11 (6; 14) years underwent a general blood test with the determination of reticulocyte parameters. The comparison group included 30 healthy children.
Results and conclusions. Revealed a significant decrease in hemoglobin (p = 0.001) less than 120 g/l in 22.9 % of patients with JIA. A statistically significant difference from the comparison group was a decrease in the average concentration of hemoglobin in an erythrocyte (p = 0.03). An increase in the content of reticulocytes with a predominance of immature forms was found in 28.8 % of patients with JIA. A decrease in the hemoglobin content in the reticulocyte and erythrocyte was detected in 28.8 and 44.9 % of cases. The systemic form of the disease affects erythropoiesis in the form of an increase in the content of reticulocytes with an increase in the content of immature forms (37.5 %), a decrease in the concentration of hemoglobin in the reticulocyte and erythrocyte (25 and 58.8 %).
References
1. Gordeeva, O. B., Botvineva V. V., Namazova-Baranova L. S. Erythrocyte and reticulocyte indices in patients with inflammatory diseases of various origins // Pediatric pharmacology. – 2012. – № 9(6). – S. 110–112.
2. Canals, C., Remacha A. F., Sardá M. P. et al. Clinical utility of the new Sysmex XE 2100 parameter-reticulocyte hemoglobin equivalent – in the diagnosis of anemia // Haematologica. – 2005. – T. 90(8). – P. 1133–1134.
3. Haemoglobin concentrations for the diagnosis of anaemia and assessment of severity // World Health Organization. – 2011. – P. 6. – Available at: https://apps.who.int/iris/handle/10665/85839.
4. Lim, A. Y., Gaffney K., Scott D. G. Methotrexate-induced pancytopenia: serious and under-reported? Our experience of 25 cases in 5 years // Rheumatology (Oxford). – 2005. – T. 44(8). – P. 1051–1055. – DOI: 10.1093/rheumatology/keh685.
Review
For citations:
Strohaya N.V. Indicators of reticulocytes and erythrocytes in assessment of anemic syndrome in juvenile idiopathic arthritis. Medical Journal. 2023;(2):104-107. (In Russ.) https://doi.org/10.51922/1818-426X.2023.2.104
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