Renin-angiotensin-aldosterone system: traditional function and pleiotropic effects of regulation of phosphorus-calcium metabolism
https://doi.org/10.51922/1818-426X.2022.1.147
Abstract
In 207 patients with different stages of CKD and 60 individuals in the comparison group, the parameters of the renin-angiotensin-aldosterone system and their relationship with renal function and PTH levels were determined. It was found that patients with CKD are characterized by a tendency towards a lower level of aldosterone in the blood serum, up to the terminal stage of CKD, as well as hyperreninemia in the early stages of CKD and its decrease with the progression of the disease. The highest incidence of hyperaldosteronism was recorded in dialysis and transplant patients. A weak correlation was found between PTH and aldosterone levels in patients with CKD. At the same time, multidirectional changes in the medians of blood concentrations of aldosterone and renin were revealed in subgroups of patients with the presence and absence of SHPT.
About the Authors
N. V. Karlovich
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
T. V. Mohort
УО «Белорусский государственный медицинский университет»
Belarus
Belarus
Y. A. Volchek
УЗ «4-я городская клиническая больница имени Н. Е. Савченко»
Belarus
Belarus
References
1. Nishiyama, A., Kobori H. Independent regulation of renin-angiotensin-aldosterone system in the kidney // Clin Exp Nephrol. – 2018. – Vol. 22(6). – Р. 1231–1239.
2. Fischer, E, Hannemann A., Rettig R., Lieb W., Nauck M., Pallauf A., Bidlingmaier M., Beuschlein F., Wallaschofski H., Reincke M. A high aldosterone to renin ratio is associated with high serum parathyroid hormone concentrations in the general population // J. Clin. Endocrinol. Metab. – 2014. – Vol. 99(3). – Р. 965–71.
3. Petramala, L., Zinnamosca L., Settevendemmie A., Marinelli C., Nardi M., Concistre A. et al. Bone and mineral metabolism in patients with primary aldosteronism //International journal of endocrinology. – 2014. – Р. 836529.
4. Zheng, M. H., Li F. X., Xu F., Lin X., Wang Y., Xu Q. S., Guo B., Yuan L. Q. The Interplay Between the Renin-Angio-tensin-Aldosterone System and Parathyroid Hormone // Front Endocrinol (Lausanne). – 2020. – № 11. – Р. 539.
5. Vaidya, A, Brown J. M, Williams J. S. The renin-angiotensin-aldosterone system and calcium-regulatory hormones // J. Hum. Hypertens. – 2015. – № 29(9). – Р. 515–21.
6. Jiang, Y., Zhang C., Ye L., Su T., Zhou W., Jiang L. et al. Factors affecting parathyroid hormone levels in different types of primary aldosteronism // Clin. Endocrinol. – 2016. – Vol. 85. – Р. 267–74.
7. Koiwa, F., Komukai D., Hirose M., Yoshimura A., Ando R., Sakaguchi T. et al. Influence of renin-angiotensin system on serum parathyroid hormone levels in uremic patients // Clin. Exp. Nephrol. – 2012. – № 16(1). – Р. 130–5.
8. Karlovich, N. V. Vtorichniy giperparatireos pri hronicheskoy bolezni pochek: monografiya / N. V. Karlovich, T. V. Mokhort; UO BGMU. – Minsk, 2021. – 177 s. [in Russian]
9. Karlovich, N. V. Vtorichniy giperparatireos, deficit vitamin D3 i narusheniya fosforno-kalcievogo obmena u pacientov s razlichnimi stadiyami hronicheskoy bolezni pochek // Lechebnoe delo. – 2016. – № 5(51). – S. 35–39 [in Russian]
10. Goncharov, P. P. Aldosteron i funkciya serdechnososudistoy sistemy (k 50-letiyu otkritiya aldosterona) // Problemy endokrinologii. – 2004. – Т. 50, № 6. – Р. 29–32 [in Russian]
11. Karlovich, N. V. Spiridonova O. S., Sazonova E. G., Mokhort T. V. Opredelenie referentnogo intervala paratgormona u pacientov s razlichnimi stadiyami hronicheskoy bolezni pochek // News of the National Academy of Sciences Belarusi. Serya medycinskih navuk. – 2020. – Т. 19, № 2. – S. 186–194 [in Russian]
Review
For citations:
Karlovich N.V., Mohort T.V., Volchek Y.A. Renin-angiotensin-aldosterone system: traditional function and pleiotropic effects of regulation of phosphorus-calcium metabolism. Medical Journal. 2022;(1):147-153. (In Russ.) https://doi.org/10.51922/1818-426X.2022.1.147
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