Experimental possibilities for studying tone in disorders contractive function of smooth myocytes

Abstract

A method has been proposed for assessing the functional state of the uterus of experimental pregnant animals, including simultaneous recording of signals from the electrical and mechanical activity of the uterus using a kymograph and an electromyocytograph. The method allows you to record the frequency and duration of uterine contractions and record a mechanogram, and timely visualize uterine hypotension during the administration of various doses of uterotonics.

This will allow us to establish the degree of development of myometrial hypotension under the influence of excessive doses of exogenous uterotonics. The combined research method will allow assessing the functional state of the uterus of a pregnant rat against the background of induced uterine contractions in an acute experiment.