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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.1.89</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-80</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS</subject></subj-group></article-categories><title-group><article-title>Влияние неаллергических факторов на уровень общего иммуноглобулина Е в сыворотке крови</article-title><trans-title-group xml:lang="en"><trans-title>Level of total serum immunoglobulin E, influence of nonallergic factors</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>T. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>89</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новикова Т.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Новикова Т.П.</copyright-holder><copyright-holder xml:lang="en">Novikova T.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/80">https://medjournal.ejournal.by/jour/article/view/80</self-uri><abstract><p>Диагностика аллергических заболеваний (АЗ) в наши дни сохраняет свою актуальность, несмотря на рост значимости инфекционной патологии. Диагностика аллергических состояний основана на определении уровня общего сывороточного и специфических иммуноглобулинов Е (ИГ Е) как ключевого звена развития реагиновой аллергической реакции. К неаллергическим факторам, оказывающим влияние на уровень оИГ Е, относят возраст пациентов, место постоянного проживания, стаж курения. В исследование включен 181 пациент, из которых 104 пациента составили группу атопия, вторую группу составили 38 пациентов с диагнозом хроническая обструктивная болезнь легких фенотип с частично обратимой обструкцией (ХОБЛ/НБА) и 39 здоровых добровольцев составили контрольную группу. Группы были сопоставимы по полу и возрасту. В исследовании оценивалось влияние неаллергических факторов на уровень оИГ E у пациентов с атопией и ХОБЛ/НБА. В результате оИГ E был выше у пациентов моложе 40 лет, проживающих в городе, со стажем курения более 10 лет. Связи между изменением липидного обмена и уровнем оИГ E не выявлено.</p></abstract><trans-abstract xml:lang="en"><p>Diagnostics of allergic diseases today remains relevant, despite the growing importance of infectious pathology. Diagnosis of allergic conditions is based on determining the level of total serum and specific immunoglobulins E (tIgE) as a key part in the allergic reaction. Non-allergic factors affecting the level of tIg E include age, gender, place of permanent residence, and smoking. The study involved 181 patients, of which 104 patients formed the atopy group, the second group consisted of 38 patients diagnosed with chronic obstructive pulmonary disease phenotype with partially reversible obstruction (COPD/NAA) and 39 healthy volunteers made up the control group. The groups were matched for gender and age. The study evaluated the influence of these factors on the level of tIg E in patients with atopy and COPD/NAA. As a result, tIg E was higher in patients under 40 years old, living in the city, with a smoking experience of more than 10 years. The relationship between the change in lipid metabolism and the level tIg E was not revealed.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>иммуноглобулин Е</kwd><kwd>бронхиальная астма</kwd><kwd>место проживания</kwd><kwd>возраст</kwd><kwd>курение</kwd><kwd>дислипидемия</kwd></kwd-group><kwd-group xml:lang="en"><kwd>immunoglobulin E</kwd><kwd>bronchial asthma</kwd><kwd>place of residence</kwd><kwd>age</kwd><kwd>smoking</kwd><kwd>dyslipidemia</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dotsenko, E. А., Turin N. S., Novikov D. K., Kolosova Т. S. Pollinoz [Allergy to Pollen] // Zdravoohranenie. – 2001. – № 2. – P. 35–39.</mixed-citation><mixed-citation xml:lang="en">Dotsenko, E. A., Turin N. S., Novikov D. K., Kolosova T. S. 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