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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.1.52</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-77</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS</subject></subj-group></article-categories><title-group><article-title>Сравнительный анализ результатов локального применения различных лекарственных форм местных фторпрепаратов in vitro</article-title><trans-title-group xml:lang="en"><trans-title>Comparative analysis of the results of local application of various dosage forms of local fluoropreparations in vitro</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Гранько</surname><given-names>С. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Granko</surname><given-names>S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Куницкая</surname><given-names>С. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Kunitskaya</surname><given-names>S.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>ГУО «Белорусская медицинская академия последипломного образования»</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>1</issue><fpage>52</fpage><lpage>60</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Гранько С.А., Куницкая С.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Гранько С.А., Куницкая С.В.</copyright-holder><copyright-holder xml:lang="en">Granko S., Kunitskaya S.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/77">https://medjournal.ejournal.by/jour/article/view/77</self-uri><abstract><p>Описаны результаты эффективности применения различных лекарственных форм местных фторпрепаратов in vitro. Объектом исследования явились интактные первые премоляры, удаленные по ортодонтическим показаниям. После удаления зубы хранились в физиологическом растворе, затем их очищали от налета щеткой и пастой, не содержащей фториды, и промывали водой. На проксимальные поверхности наносили препарат линейки Flairesse (DMG, Германия) для местной фторпрофилактики по инструкции, рекомендованной производителем. Во всех исследуемых группах регистрировали глубину проникновения ионов фтора в эмаль до 20 мкм. Разность в уровнях излучения существенна (p = 0,0125). Группы зубов с очагом подповерхностной деминерализации, сформированным в лабораторных условиях, на поверхность которых наносили фторсодержащие препараты (группы сравнения) имели статистически значимо более высокие концентрации фторид ионов на глубине 15 мкм, чем зубы с кариесом эмали в стадии пятна на проксимальной поверхности, на которые не наносили фторсодержащие препараты (контроль) (p &lt; 0,0125).</p></abstract><trans-abstract xml:lang="en"><p>The aim of this research was to study the effectiveness of different medicinal forms of the products for local fluorine prophylaxis in vitro. The object of study was the intact first premolars removed on orthodontic indications. The extracted teeth were kept in saline solution. Then the Flairesse line product (DMG, Germany) for local fluorine prophylaxis (on the producer’s instruction) was applied onto the proximal surfaces. In all studied groups the depth of penetration into an enamel of ions of fluorine was recorded up to 20 мm. The difference in radiation levels is significant (p = 0.0125). Groups of teeth with a focus of subsurface demineralization formed under laboratory conditions, on the surface of which fluorine-containing preparations were applied (comparison groups), had statistically significantly higher concentrations of fluoride ions at a depth of 15 html5-dom-document-internal-entity2-956-endm than teeth with enamel caries in the stage of spots on the proximal surface, on which fluorine-containing preparations were applied (control) (p &lt; 0.0125).</p></trans-abstract><kwd-group xml:lang="ru"><kwd>фторпрофилактика</kwd><kwd>профилактика кариеса зубов</kwd><kwd>кариес эмали в стадии пятна</kwd><kwd>искусственные очаги подповерхностной деминерализации</kwd></kwd-group><kwd-group xml:lang="en"><kwd>fluorine-prevention</kwd><kwd>dental caries prevention</kwd><kwd>enamel caries</kwd><kwd>artificial areas of subsurface demineralization</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Боровский, Е. 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