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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.2.107</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-50</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS</subject></subj-group></article-categories><title-group><article-title>Влияние грудного вскармливания на антропометрические показатели и гормональный статус крупновесных и маловесных детей в динамике первых двух лет жизни</article-title><trans-title-group xml:lang="en"><trans-title>Influence of breastfeeding on anthropometric indicators and hormonal status of large and small for gestational age children in the dynamics of the first two years of life</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Прилуцкая</surname><given-names>В. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Prylutskaya</surname><given-names>V. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Сукало</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Sukalo</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>107</fpage><lpage>113</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Прилуцкая В.А., Сукало А.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Прилуцкая В.А., Сукало А.В.</copyright-holder><copyright-holder xml:lang="en">Prylutskaya V.A., Sukalo A.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/50">https://medjournal.ejournal.by/jour/article/view/50</self-uri><abstract><p>Важнейшими регуляторами скорости роста и физического развития у детей являются рациональное питание и гормоны. Цель – оценить влияние грудного вскармливания на антропометрические показатели и гормональный профиль крупновесных и маловесных детей в динамике первых двух лет жизни. Обследовано 280 доношенных новорожденных с динамическим наблюдением в течение 2 лет жизни. Основная группа 1 (Гр1) – 110 крупновесных к сроку гестации, Гр2 – 95 маловесных к сроку гестации, группа контроля – 72 с соответствующими сроку гестации показателями. Проанализирована динамика антропометрических показателей, характера вскармливания, нутритивного и гормонального статусов детей с учетом массы тела при рождении. Установлено, что младенцы с низкой массой тела при рождении на протяжении первого года жизни значимо реже получают исключительно грудное молоко. Доля детей, получавших исключительно грудное вскармливание в неонатальном периоде, ниже показателя контрольной группы (р = 0,002). Установлены корреляционные взаимосвязи продолжительности грудного вскармливания с показателями физического развития и адипокинового статуса у новорожденных и детей раннего возраста. У трехмесячных маловесных детей, получавших заменители грудного молока, выявлены более высокий уровень ИФР-1 (р = 0,047) и более низкая концентрация адипонектина (р = 0,045) сыворотки крови, у крупновесных – более высокое содержание ИФР-1 (р = 0,029) и инсулина (р = 0,015). Выявленные особенности антропометрического и гормонального статусов обосновывают важность обеспечения условий для длительного грудного вскармливания, преемственности при оказании медицинской помощи маловесным и крупновесным младенцам, проведение образовательно-просветительской работы с родителями.</p></abstract><trans-abstract xml:lang="en"><p>The most important regulators of the rate of growth and physical development in children are rational nutrition and hormones. The aim is to evaluate the effect of breastfeeding on the anthropometric parameters and hormonal profile of large and small for gestational age children in the dynamics of the first two years of life. 280 full-term newborns were examined with dynamic follow-up during 2 years of life. The main group 1 (Gr1) – 110 large for gestational age, Gr2 – 95 small for gestational age, the control group – 72 with indicators corresponding to the gestational age. The dynamics of anthropometric indicators, the nature of feeding, nutritional and hormonal status were analyzed, taking into account body weight at birth. It has been established that infants with low birth weight during the first year of life are significantly less likely to receive exclusively breast milk. The proportion of children who received exclusive breastfeeding in the neonatal period is lower than in the control group (p = 0.002). Correlations between the duration of breastfeeding and indicators of physical development and adipokines status in newborns and young children have been established. Threemonth-old low birth weight infants treated with breast milk substitutes showed a higher level of IGF-1 (p = 0.047) and a lower concentration of adiponectin (p = 0.045) in blood serum. In large for gestational age infants, a higher content of IGF-1 (p = 0.029) and insulin (p = 0.015) was established. The revealed features of anthropometric and hormonal status substantiate the importance of providing conditions for long-term breastfeeding, continuity in the provision of medical care to small and large for gestational age babies, and educational work with parents.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>дети</kwd><kwd>грудное молоко</kwd><kwd>крупновесный к сроку гестации</kwd><kwd>маловесный к сроку гестации</kwd><kwd>новорожденный</kwd><kwd>физическое развитие</kwd><kwd>адипокины</kwd></kwd-group><kwd-group xml:lang="en"><kwd>children</kwd><kwd>breast milk</kwd><kwd>large for gestational age</kwd><kwd>small for gestational age</kwd><kwd>newborn</kwd><kwd>physical development</kwd><kwd>adipokines</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Briana, D. D., Boutsikou M., Boutsikou T., Malamitsi-Puchner A. 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