<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.2.91</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-45</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS</subject></subj-group></article-categories><title-group><article-title>Влияние аллергических факторов на уровень общего иммуноглобулина Е в сыворотке крови</article-title><trans-title-group xml:lang="en"><trans-title>Influence of allergic factors on level of total serum immunoglobulin E</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Новикова</surname><given-names>Т. П.</given-names></name><name name-style="western" xml:lang="en"><surname>Novikova</surname><given-names>T. P.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>17</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>2</issue><fpage>91</fpage><lpage>94</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Новикова Т.П., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Новикова Т.П.</copyright-holder><copyright-holder xml:lang="en">Novikova T.P.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/45">https://medjournal.ejournal.by/jour/article/view/45</self-uri><abstract><p>Диагностика аллергических заболеваний на ранних стадиях важна в наши дни, несмотря на рост значимости инфекционной патологии. Базовыми тестами для аллергодиагностики является определение уровня общего сывороточного и специфических сывороточных иммуноглобулинов Е (ИГ Е), как ключевого звена развития реагиновой аллергической реакции. К аллергическим факторам, оказывающим влияние на уровень общего сывороточного ИГ Е (оИГ Е) относят характер и степень сенсибилизации пациентов к одной или нескольким группам аллергенов.В исследовании включен 143 пациент, из которых 104 пациента с атопией были разделены на группу пациентов аллергической бронхиальной астмой в сочетании с аллергическим ринитом (58 пациентов) и группу пациентов с аллергическим ринитом (46 пациентов). 39 здоровых добровольцев составили контрольную группу. Группы были сопоставимы по полу и возрасту. В исследовании оценивалось влияние аллергических факторов на уровень оИГ E у пациентов с аллергическими заболеваниями. Более высокие значения оИГ Е общего получены у пациентов с аллергической бронхиальной астмой и полисенсибилизацией. Около половины пациентов с ринитом и более 15 % пациентов с астмой имеют нормальный уровень оИГ Е, что обуславливает необходимость выработки новых подходов в оценке нормальных значений этого маркера аллергии.</p></abstract><trans-abstract xml:lang="en"><p>The correct diagnosis of allergic diseases at the early stages is important nowadays, despite the growing importance of infectious pathology. The basic tests for allergy diagnosis are the determination of the level of total serum and specific immunoglobulins E (Ig E), as a key link in the development of type1 allergic reaction. Allergic factors affecting the level of Ig E include the nature and degree of sensitization of patients to one or more groups of allergens.The study included 143 patients, of which 104 patients with atopy were divided into allergic asthma + allergic rhinitis patient’s group (58 patients) and group of 46 patients who had just allergic rhinitis. 39 healthy volunteers were the control group. The groups were matching by gender and age. The study evaluated the influence of allergic factors on the level of total Ig E in patients with allergic diseases. Higher values of Ig E total were obtained in patients with allergic asthma and polysensitization. About half of patients with rhinitis and 15 % of patients with asthma have normal total Ig E level, that is one of the reasons to change approaches to normal values of this allergy marker.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>иммуноглобулин Е</kwd><kwd>аллергический ринит</kwd><kwd>астма</kwd><kwd>сенсибилизация</kwd><kwd>аллерген</kwd></kwd-group><kwd-group xml:lang="en"><kwd>immunoglobulin E</kwd><kwd>allergic rhinitis</kwd><kwd>asthma</kwd><kwd>sensitization</kwd><kwd>allergen</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Dotsenko, E. А., Turin N. S., Novikov D. K., Kolosova Т. S. Pollinoz [Allergy to Pollen] // Zdravoohranenie. – 2001. – № 2. – P. 35–39.</mixed-citation><mixed-citation xml:lang="en">Dotsenko, E. А., Turin N. S., Novikov D. K., Kolosova Т. S. Pollinoz [Allergy to Pollen] // Zdravoohranenie. – 2001. – № 2. – P. 35–39.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Klinicheskie rekomendacii Allergicheskij rinit(AR) MKB10: J30 / J30.1 / J30.2 / J30.3 / J30.4 [Clinical recommendations Allergic rhinitis(AR) ICD10: J30 / J30.1 / J30.2 / J30.3 / J30.4], 2016, available at: http://nrcii.ru/docs/2.allergic_rhinitis.pdf.</mixed-citation><mixed-citation xml:lang="en">Klinicheskie rekomendacii Allergicheskij rinit(AR) MKB10: J30 / J30.1 / J30.2 / J30.3 / J30.4 [Clinical recommendations Allergic rhinitis(AR) ICD10: J30 / J30.1 / J30.2 / J30.3 / J30.4], 2016, available at: http://nrcii.ru/docs/2.allergic_rhinitis.pdf.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Klinicheskie rekomendacii Bronhialnaya asthma MKB10 (Clinical recommendations Bronchial asthma ICD10: J.45, J.46). – M.: Russian Respiratory Society, 2016. – 76 p.</mixed-citation><mixed-citation xml:lang="en">Klinicheskie rekomendacii Bronhialnaya asthma MKB10 (Clinical recommendations Bronchial asthma ICD10: J.45, J.46). – M.: Russian Respiratory Society, 2016. – 76 p.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Macharadze, D. Sh., Sovremenniye klinicheskiye aspekty otsenki urovney obschego I specificheskih IgE (Modern clinical aspects of evaluation of total and specific IgE) // Pediatriya. – 2017. – Vol. 96(2). – P. 121–127.</mixed-citation><mixed-citation xml:lang="en">Macharadze, D. Sh. Sovremenniye klinicheskiye aspekty otsenki urovney obschego I specificheskih IgE (Modern clinical aspects of evaluation of total and specific IgE) // Pediatriya. – 2017. – Vol. 96 (2). – P. 121–127.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Prilutski, A. S., Maylyan, E. A., Prilutskaya, O. A. et al. Urovenj immunoglobulina E u zdorovih i strdajuschih allergicheskimi zabolevaniyami lits (Level of immunoglobulin E in healthy humans and patients, suffering from allergic diseases) // Asthma ta Allergiya. – 2002. – № 1. – P. 17–19.</mixed-citation><mixed-citation xml:lang="en">Prilutski, A. S., Maylyan E. A., Prilutskaya O. A. et al. Urovenj immunoglobulina E u zdorovih i strdajuschih allergicheskimi zabolevaniyami lits (Level of immunoglobulin E in healthy humans and patients, suffering from allergic diseases) // Asthma ta Allergiya. – 2002. – № 1. – P. 17–19.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Global Initiative for Asthma. Global strategy for asthma management and prevention 2020, available at: htpp://ginasthma.org.</mixed-citation><mixed-citation xml:lang="en">Global Initiative for Asthma. Global strategy for asthma management and prevention 2020, available at: htpp://ginasthma.org.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Thomas, A. E. Platts- Mills, Alexander J Shuyler, Elizabeth A Erwin et al. IgE in Clinical Allergy and Allergy Diagnosis, available at: http://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/ige-in-clinical-allergy-and-allergy-diagnosis#</mixed-citation><mixed-citation xml:lang="en">Thomas, A. E. Platts-Mills, Alexander J Shuyler, Elizabeth A Erwin et al. IgE in Clinical Allergy and Allergy Diagnosis, available at: http://www.worldallergy.org/education-and-programs/education/allergic-disease-resource-center/professionals/ige-in-clinical-allergy-and-allergy-diagnosis#</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Sarah, K. Wise, Sandra Y. Lin, Elina Toskala et al. International Consensus Statement on Allergy and Rhinology // Allergic Rhinitis, International Forum of Allergy &amp; Rhinology. – 2018. – Vol. 8, № 2. – P. 108–352.</mixed-citation><mixed-citation xml:lang="en">Sarah, K. Wise, Sandra Y. Lin, Elina Toskala et al. International Consensus Statement on Allergy and Rhinology // Allergic Rhinitis, International Forum of Allergy &amp; Rhinology. – 2018. – Vol. 8, № 2. – P. 108–352.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Teresa, T., Sanja Stanojevich, Ginette Moores et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey // BMC Public Health. – 2012. – P. 204. – Available at: http://www.biomedcentral.com/1471-2458/12/204.</mixed-citation><mixed-citation xml:lang="en">Teresa, T., Sanja Stanojevic1, Ginette Moores et al. Global asthma prevalence in adults: findings from the cross-sectional world health survey // BMC Public Health. – 2012. – P. 204. – Available at: http://www.biomedcentral.com/1471-2458/12/204.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
