medjournalМедицинский журналMedical Journal1818-426XБелорусский государственный медицинский университет10.51922/1818-426X.2026.1.5medjournal-388Research ArticleОБЗОРЫREVIEWSИнкрустация мочеточникового стента: возможности медикаментозной профилактикиUreteral stent encrustation: possibilities of drug prophylaxisГаврусевА. А.GavrusevA. A.

Минск

Minsk

ЧохелиГ.ChokheliG.

Минск

Minsk

ЕфимчикН. А.EfimchikN. A.

Минск

Minsk

НиткинД. М.NitkinD. M.

Минск

Minsk

УО «Белорусский государственный медицинский университет»Belarusian State Medical UniversityУЗ «4-я городская клиническая больница им. Н. Е. Савченко»4th City Clinical Hospital named after N. E. Savchenko20261603202601510Copyright © Гаврусев А.А., Чохели Г., Ефимчик Н.А., Ниткин Д.М., 20262026Гаврусев А.А., Чохели Г., Ефимчик Н.А., Ниткин Д.М.Gavrusev A.A., Chokheli G., Efimchik N.A., Nitkin D.M.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medjournal.ejournal.by/jour/article/view/388

Стентирование мочеточников в большинстве случаев проводят при уростазе на фоне мочекаменной болезни, при остром обструктивном пиелонефрите. Среди осложнений стентирования наиболее клинически важными являются инфекция мочевыводящих путей и инкрустация стента. Меры профилактики осложнений стентирования мочеточников до настоящего времени не разработаны. В статье представлен обзор литературных данных по перспективным лекарственным средствам, которые могут быть использованы в профилактике инфекции мочевыводящих путей, ассоциированной с мочеточниковыми стентами и профилактике их инкрустаций.

Ureteral stenting is most often performed for urinary stasis secondary to urolithiasis and acute obstructive pyelonephritis. Among stenting complications, the most clinically significant are urinary tract infection and stent encrustation. Preventive measures for ureteral stenting complications have not yet been developed. This article presents a literature review of promising medications that can be used to prevent urinary tract infection associated with ureteral stents and their encrustation.

мочеточниковый стентбиопленкиинкрустация стентаинфекция мочевыводящих путеймедикаментозная профилактикаобструктивный пиелонефритureteral stentbiofilmsstent encrustationurinary tract infectiondrug prophylaxisobstructive pyelonephritisReferencesA randomized clinical trial evaluating the short term results of ureteral stent encrustation in urolithiasis patients undergoing ureteroscopy: micro computed tomography evaluation / T. Yoshida [et al.] // Scientific Reports. – 2021. – Vol. 11. – Р. 10337. – doi: 10.1038/s41598-02189808-x.A randomized clinical trial evaluating the short term results of ureteral stent encrustation in urolithiasis patients undergoing ureteroscopy: micro computed tomography evaluation / T. Yoshida [et al.]. // Scientific Reports. – 2021. – Vol. 11. – Р. 10337. – doi: 10.1038/s41598-02189808-x.Role of ureteral stent material and coating to prevent ureteral stent related issue: A systematic review and meta analysis / I. I. Putrantyo [et al.] // Archivio Italiano di Urologia e Andrologia. – 2024. – 96. – Vol. 1. – P. 12067. – doi: 10.4081/aiua.2024.12067.Role of ureteral stent material and coating to prevent ureteral stent related issue: A systematic review and meta analysis. / I. I. Putrantyo [et al.]. // Archivio Italiano di Urologia e Andrologia. – 2024. – 96. – Vol. 1. – P. 12067. – doi: 10.4081/aiua.2024.12067.Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin / J. Bouckaert [et al.]. // Molecular Microbiology. – 2005. – Vol. 55, iss. 2. – P. 441–455. – doi: 10.1111/j.13652958.2004.04415.x.Receptor binding studies disclose a novel class of high-affinity inhibitors of the Escherichia coli FimH adhesin / J. Bouckaert [et al.] // Molecular Microbiology. – 2005. – Vol. 55, iss. 2. – P. 441–455. – doi: 10.1111/j.13652958.2004.04415.x.D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis / S. M. Lenger [et al.] // Am J Obstet Gynecol. – 2020. – Vol. 223, iss. 2. – P. 265.e1–265.e13. – doi: 10.1016/j.ajog.2020.05.048.D-mannose vs other agents for recurrent urinary tract infection prevention in adult women: a systematic review and meta-analysis / S. M. Lenger [et al.] // Am J Obstet Gynecol. – 2020. – Vol. 223, iss. 2. – P. 265.e1–265.e13. – doi: 10.1016/j.ajog.2020.05.048.A prospective randomized study to define the role of low dose continuous prophylactic antibiotics and antiadherence agents in altering the microbial colonization related to indwelling double-J stents / K. Madhavan [et al.] // Asian Journal of Urology. – 2021. – Vol. 8. – P. 269–274. – doi: 10.1016/j.ajur.2020.08.003.A prospective randomized study to define the role of low dose continuous prophylactic antibiotics and antiadherence agents in altering the microbial colonization related to indwelling double-J stents / K. Madhavan [et al.] // Asian Journal of Urology. – 2021. – Vol. 8. – P. 269–274. – doi: 10.1016/j.ajur.2020.08.003.Профилактика развития катетер-ассоциированных инфекций мочевыделительной системы у пациентов в раннем послеоперационном периоде / А. С. АльШукри [и др.] // Урология. – 2023. – № 2. – С. 13–19. – doi: 10.18565/urology.2023.2.13-19.Profilaktika razvitiya kateter-associirovannyh infekcij mochevydelitel’noj sistemy u pacientov v rannem posleoperacionnom periode / A. S. Al’-Shukri [et al.] // Urologiya. – 2023. – № 2. – S. 13–19. – doi: 10.18565/urology.2023. 2.13-19.Reduction of ureteral stent encrustation by modulating the urine pH and inhibiting the crystal film with a new oral composition: a multicenter, placebo controlled, double blind, randomized clinical trial / C. Torrecilla [et al.] // BMC Urology. – 2020. – Vol. 20. – P. 65. – doi: 10.1186/s12894-020-00633-2.Reduction of ureteral stent encrustation by modulating the urine pH and inhibiting the crystal film with a new oral composition: a multicenter, placebo controlled, double blind, randomized clinical trial / C. Torrecilla [et al.] // BMC Urology. – 2020. – Vol. 20. – P. 65. – doi: 10.1186/s12894-020-00633-2.Effect of phytate on crystallization on ureteral stents and bacterial attachment: an in vitro study / P. Calvó [et al.] // Urolithiasis. – 2022. – Vol. 50. – P. 737–742. – doi: org/10.1007/s00240-022-01350-1.Effect of phytate on crystallization on ureteral stents and bacterial attachment: an in vitro study. / P. Calvó [et al.] // Urolithiasis. – 2022. – Vol. 50. – P. 737–742. – doi: org/10.1007/s00240-022-01350-1.Single-center, double-blind, randomized, placebocontrolled pilot study of Canoxidin® for prevention of catheter encrustation in patients with indwelling catheters / A. Borau [et al.] // Actas Urol Esp (Engl Ed). – 2024 – Vol. 48, iss. 9. – P. 658–664. – doi: 10.1016/j.acuroe.2024.06.004.Single-center, double-blind, randomized, placebocontrolled pilot study of Canoxidin® for prevention of catheter encrustation in patients with indwelling catheters / A. Borau [et al.] // Actas Urol Esp (Engl Ed). – 2024 – Vol. 48, iss. 9. – P. 658–664. – doi: 10.1016/j.acuroe.2024.06.004.Обидняк, В. М. Мочеточниковые стенты: экспериментальная оценка свойств и новые подходы к профилактике осложнений: дис. … канд. мед. наук / В. М. Обидняк [Электронный ресурс]. – Режим доступа: https://disser.spbu.ru/files/2025/disser_obidnyak.pdf. – Дата доступа: 26.09.2025.Obidnyak, V. M. Mochetochnikovye stenty: eksperimental’naya ocenka svojstv i novye podhody k profilaktike oslozhnenij: dis. … kand. med. nauk / V. M. Obidnyak [Electronic resource]. – Access of mode: https://disser.spbu.ru/files/2025/disser_obidnyak.pdf. – Access of date: 26.09.2025.The Composition of Catheter Encrustations, including the Effects of Allopurinol Treatment / H. Hedelin [et al.] // British Journal of Urology. – 1984. – Vol. 56. – P. 250–254.The Composition of Catheter Encrustations, including the Effects of Allopurinol Treatment / H. Hedelin [et al.] // British Journal of Urology. – 1984. – Vol. 56. – P. 250–254.Does potassium citrate administration change the type and composition of encrusted material on Double J stent compared to primary stone? / A. Mohammadi [et al.] // International Urology and Nephrology. – 2021. – Vol. 53. – P. 1797–1803. – doi: 10.1007/s11255-021-02891-x.Does potassium citrate administration change the type and composition of encrusted material on Double J stent compared to primary stone? / A. Mohammadi [et al.] // International Urology and Nephrology. – 2021. – Vol. 53. – P. 1797–1803. – doi: 10.1007/s11255-021-02891-x.Comparison of the effects of potassium citrate and hydrochlorothiazide on the ureteral stent encrustation in patients with long stent survival; a single-blinded clinical trial / S. Farshid [et al.] // J Renal Inj Prev. – 2022. – Р. e25804. – doi: 10.34172/jrip.2022.25804.Comparison of the effects of potassium citrate and hydrochlorothiazide on the ureteral stent encrustation in patients with long stent survival; a single-blinded clinical trial / S. Farshid [et al.] // J Renal Inj Prev. – 2022. – Р. e25804. – doi: 10.34172/jrip.2022.25804.Does alkalinised urine reduce the rate of encrustation in patients with ureteric stents? A randomised controlled study / L. S. Ch’ng [et al.] // International Urology and Nephrology. – 2022. – Vol. 54. – P. 509–515. – doi: 10.1007/s11255-022-03105-8.Does alkalinised urine reduce the rate of encrustation in patients with ureteric stents? A randomised controlled study / L. S. Ch’ng [et al.] // International Urology and Nephrology. – 2022. – Vol. 54. – P. 509–515. – doi: 10.1007/s11255-022-03105-8.Особенности инкрустации мочеточниковых стентов у пациентов с кальций-оксалатными и мочекислыми конкрементами / А. А. Пранович [и др.] // Урология. – 2023. – № 2. – С. 26–31. – doi: 10.18565/urology.2023. 2.26-31.Osobennosti inkrustacii mochetochnikovyh stentov u pacientov s kal’cij-oksalatnymi i mochekislymi konkrementami / A. A. Pranovich [et al.] // Urologiya. – 2023. – № 2. – S. 26–31. – doi: 10.18565/urology.2023.2.26-31.Мочекаменная болезнь: опыт применения и эффективность Канефрона®Н. / А. А. Гресь, В. И. Вощула, И. Л. Рыбина [и соавт.] // Медицинские новости. – 2004. – № 8. – С. 89–93.Mochekamennaya bolezn’: opyt primeneniya i effektivnost’ Kanefrona®N. / A. A. Gres’, V. I. Voshchula, I. L. Rybina [i soavt.] // Medicinskie novosti. – 2004. – № 8. – S. 89–93.

The authors declare that there are no conflicts of interest present.