<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.3.137</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-282</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>ОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>ORIGINAL SCIENTIFIC PUBLICATIONS</subject></subj-group></article-categories><title-group><article-title>Анализ микробиологического мониторинга возбудителей нозокомиальных инфекций в отделениях интенсивной терапии хирургического и терапевтического профиля</article-title><trans-title-group xml:lang="en"><trans-title>Analysis of microbiological monitoringof excitation of hospital infections in the intensive care unit of surgical and therapeutic</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Якубцевич</surname><given-names>Р. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Yakubcevich</surname><given-names>R. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Лемеш</surname><given-names>А. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Lemesh</surname><given-names>A. V.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Чернова</surname><given-names>Н. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Chernova</surname><given-names>N. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Балла</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Balla</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-2"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Арутюнян</surname><given-names>Д. Э.</given-names></name><name name-style="western" xml:lang="en"><surname>Arutyunyan</surname><given-names>D. E.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Казукевич</surname><given-names>А. А.</given-names></name><name name-style="western" xml:lang="en"><surname>Kazukevich</surname><given-names>A. A.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-3"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Гродненский государственный медицинский университет»</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-2"><institution>УЗ «Гродненская университетская клиника»</institution><country>Belarus</country></aff><aff xml:lang="ru" id="aff-3"><institution>УО «Гродненский государственный медицинский университет», УЗ «Гродненская университетская клиника»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>22</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>137</fpage><lpage>142</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Якубцевич Р.Э., Лемеш А.В., Чернова Н.Н., Балла А.А., Арутюнян Д.Э., Казукевич А.А., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Якубцевич Р.Э., Лемеш А.В., Чернова Н.Н., Балла А.А., Арутюнян Д.Э., Казукевич А.А.</copyright-holder><copyright-holder xml:lang="en">Yakubcevich R.E., Lemesh A.V., Chernova N.N., Balla A.A., Arutyunyan D.E., Kazukevich A.A.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/282">https://medjournal.ejournal.by/jour/article/view/282</self-uri><abstract><p>Растущая распространенность мультирезистентных патогенов представляет собой огромную проблему для современной медицины, а особенно это актуально для пациентов отделений интенсивной терапии (ОИТ). В данной статье приведены результаты мониторинга изолятов микроорганизмов и их устойчивости к антибиотикам в ОИТ терапевтического и хирургического профилей. В результате исследования были получены следующие результаты: наибольшую чувствительность Klebsiellapneumoniae в терапевтической реанимации проявляет к колистину (100 %) и тигециклину (100 %), в хирургической – к бета­лактамазам расширенного спектра (ESBL – extended­spectrum beta­lactamase) (93,2 %) и тетрациклину (58,9 %); Acinetobacter baumanii: в терапевтической – к колистину (100 %), в хирургической – к колистину (100 %); Коагулазоотрицательные стафилококки: в терапевтической – к нитрофурантоину, линезолиду, тигециклину, ванкомицину (100 %); Staphylococcusaureus: в терапевтической – выработана устойчивость к большинству применяемых препаратов, за исключением бензилпенициллина;Pseudomonas aeruginosa: в терапевтической – колистин (100 %), в хирургической – к колистину (100 %). Данное исследование подчеркивает важность междисциплинарного взаимодействия врачей стационаров, в том числе ОИТ с клиническими бактериологами и эпидемиологами, а также роль своевременной коррекция антибиотикотерапии.</p></abstract><trans-abstract xml:lang="en"><p>The growing prevalence of multidrug­resistant pathogens is a huge challenge for modern medicine, and this is especially true for patients in intensive care units (ICU). This article presents the results of monitoring the isolates of microorganisms and their resistance to antibiotics in the ICU of therapeutic and surgical profiles. As a result of the study, the following results were obtained: the greatest sensitivity of Klebsiellapneumoniae in therapeutic resuscitation is shown to colistin (100 %) and tigecycline (100 %), in surgical resuscitation – to extended­spectrum beta­lactamase (ESBL) (93.2 %) and tetracycline (58.9 %); Acinetobacter baumanii: in the therapeutic – to colistin (100 %), in the surgical – to colistin (100 %); Coagulase­negative staphylococci: in the therapeutic – to nitrofurantoin, linezolid, tigecycline, vancomycin (100 %); Staphylococcusaureus: in the therapeutic field – resistance to most of the drugs used, with the exception of benzylpenicillin; Pseudomonas aeruginosa: in the therapeutic – colistin (100 %), in the surgical – to colistin (100 %). This study emphasizes the importance of interdisciplinary interaction of hospital doctors, including ICUs with clinical bacteriologists and epidemiologists, as well as the role of timely correction of antibiotic therapy.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>нозокомиальная инфекция</kwd><kwd>антибактериальная терапия</kwd><kwd>отделения интенсивной терапии</kwd><kwd>антибактериальная чувствительность</kwd></kwd-group><kwd-group xml:lang="en"><kwd>nosocomial infection</kwd><kwd>antibacterial therapy</kwd><kwd>intensive care units</kwd><kwd>antibacterial sensitivity</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Тапальский, Д. В., Савченко О. И., Бонда Н. А. Распространенность Klebsiella pneumoniae – продуцентов карбапенемаз в Гомельской области Беларуси и их чувствительность к антибиотикам, комбинациям антибиотиков, дезинфектантам // Инфекция и иммунитет. – 2019. – № 9 – S. 671–679.</mixed-citation><mixed-citation xml:lang="en">Tapal’skij, D. V., Savchenko O. I., Bonda N. A. Rasprostranennost’ Klebsiella pneumoniae – produtsentov karbapenemaz v Gomel’skoj oblasti Belarusi i ih chuvstvitel’nost’ k antibiotikam, kombinatsijam antibiotikov, dezinfektantam // Infektsija i immunitet. – 2019. – № 9. – S. 671–679.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Alverdy, J. C., Burke D. Total parenteral nutrition: iatrogenic immuno-suppression // Nutrition. – 1992. – Vol. 8. – P. 359–365.</mixed-citation><mixed-citation xml:lang="en">Alverdy, J. C., Burke D. Total parenteral nutrition: iatrogenic immuno-suppression // Nutrition. – 1992. – Vol. 8. – P. 359–365.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Bardi, T., Pintado V. et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome // Eur. J. Clin. Microbiol. In-fect Dis. – 2021. – Vol. 40, iss. 3. –P. 495–502.</mixed-citation><mixed-citation xml:lang="en">Bardi, T., Pintado V. et al. Nosocomial infections associated to COVID-19 in the intensive care unit: clinical characteristics and outcome // Eur. J. Clin. Microbiol. In-fect Dis. – 2021. – Vol. 40, iss. 3. – P. 495–502.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Geffers, C., Zuschneid I. et al. Microbiological isolates associated with nosocomial infections in intensive care units: data of 274 intensive care units participating in the German Nosocomial Infections Surveillance System (KISS) // Anasthesiol In-tensivmed Notfallmed Schmerzther. – 2004. – Vol. 39, iss. 1. – P. 15–19.</mixed-citation><mixed-citation xml:lang="en">Geffers, C., Zuschneid I. et al. Microbiological isolates associated with nosocomial infections in intensive care units: data of 274 intensive care units participating in the German Nosocomial Infections Surveillance System (KISS) // Anasthesiol In-tensivmed Notfallmed Schmerzther. – 2004. – Vol. 39, iss. 1. – P. 15–19.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Greathouse, K. C., Hall M. W. Critical Illness-Induced Immune Suppression: Current State of the Science // Am J Crit Care. – 2016. – Vol. 25, iss. 1. – P. 85–92.</mixed-citation><mixed-citation xml:lang="en">Greathouse, K. C., Hall M. W. Critical Illness-Induced Immune Suppression: Current State of the Science // Am J. Crit Care. – 2016. – Vol. 25, iss. 1. – P. 85–92.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Paterson, D. L. Restrictive antibiotic policies are appropriate in intensive care units // Crit Care Med. – 2003. – Supp. 1. – P. 25–28.</mixed-citation><mixed-citation xml:lang="en">Paterson, D. L. Restrictive antibiotic policies are appropriate in intensive care units // Crit Care Med. – 2003. – Supp. 1. – P. 25–28.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Remschmidt, Cornelius &amp; Schneider et al. Surveillance of Antibiotic Use and Resistance in Intensive Care Units (SARI) // Deutsches Arzteblatt international. – 2017. – Vol. 114. – P. 858–865.</mixed-citation><mixed-citation xml:lang="en">Remschmidt, Cornelius &amp; Schneider et al. Surveillance of Antibiotic Use and Resistance in Intensive Care Units (SARI) // Deutsches Arzteblatt international. – 2017. – Vol. 114. – P. 858–865.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Ubeda, C., Taur Y. et al. Vancomycin-resistant Enterococcus domination of in-testinal microbiota is enabled by antibiotic treatment in mice and precedes blood-stream invasion in humans // Clin Invest. – 2010. – Vol. 120, iss. 12. – P. 4332–4341.</mixed-citation><mixed-citation xml:lang="en">Ubeda, C., Taur Y. et al. Vancomycin-resistant Enterococcus domination of in-testinal microbiota is enabled by antibiotic treatment in mice and precedes blood-stream invasion in humans // Clin Invest. – 2010. – Vol. 120, iss. 12. – P. 4332–4341.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
