medjournalМедицинский журналMedical Journal1818-426XБелорусский государственный медицинский университет10.51922/1818-426X.2022.3.55medjournal-268Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИORIGINAL SCIENTIFIC PUBLICATIONSВлияние вакцинопрофилактики на заболеваемость студентов инфекцией COVID-19The impact of vaccination on the incidence of students COVID-19 infectionБуравскийА. В.BuravskyA. V.БондареваА. А.BondarevaA. A.УО «Белорусский государственный медицинский университет», 2-я кафедра хирургических болезней, Минск, БеларусьBelarus202222062025035559Copyright © Буравский А.В., Бондарева А.А., 20252025Буравский А.В., Бондарева А.А.Buravsky A.V., Bondareva A.A.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medjournal.ejournal.by/jour/article/view/268

На протяжении последних двух лет COVID­19 продолжает оставаться общемировой проблемой. Масштабная вакцинация населения направлена на достижение коллективного иммунитета (присутствие 80 % и более иммунных людей в популяции) и скорейшее завершение пандемии с наименьшими человеческими потерями. Цель работы: оценить влияние вакцинопрофилактики на заболеваемость инфекцией COVID­19 студентов лечебного факультета Белорусского государственного медицинского университета. В ходе исследования получены сведения о случаях инфекции COVID­19 у студентов (общая выборка N = 351 человек) с начала 2020 года по 31 декабря 2021 года, а также данные о специфической профилактике различными вариантами вакцин. В группе невакцинированных студентов инфекцией COVID­19 переболели 46,15 %. Среди вакцинированных по состоянию на 31 декабря 2021 года студентов (n = 249 человек) инфекцией COVID­19 переболели после вакцинации 9,24 %. Сравнительный анализ не выявил значимых различий эффективности между двумя наиболее часто используемыми в 2021 году в Республике Беларусь вакцинами – Спутник V (Gam­COVID­Vak) и Vero Cell (Sinopharm). После достижении коллективного иммунитета (на 1 ноября 2021 года пул условно иммунных студентов достиг значения 79,20 % общей выборки) в ноябре и декабре 2021 года были зарегистрированы лишь единичные случаи заболевания.

Over the past two years, COVID­19 has continued to be a worldwide problem. Large­scale vaccination of the population is aimed at achieving herd immunity. The presence of 80 % or more immune people in the population should lead to the end of the pandemic with the least human losses. The purpose of the study: to assess the impact of vaccination on the incidence of COVID­19 infection among students of the medical faculty of the Belarusian State Medical University. Information on cases of COVID­19 infection among students (total sample N = 351 people) from the beginning of 2020 to December 31, 2021, as well as data on specific prophylaxis with various vaccine options, were obtained. In the group of unvaccinated students, 46,15 % were ill with COVID­19 infection; among vaccinated students (n = 249 people), 9,24 % had COVID­19 infection after vaccination – as of December 31, 2021. A comparative analysis did not reveal significant differences in efficacy between the two most commonly used vaccines in 2021 in the Republic of Belarus – Sputnik V (Gam­COVID­Vak) and Vero Cell (Sinopharm). After the achievement of herd immunity (as of November 1, 2021, the pool of conditionally immune students reached 79,20 % of the total sample), only isolated cases of the disease were registered in November and December 2021.

COVID-19заболеваемостьвакцинопрофилактикаCOVID-19incidencevaccinationReferencesAn open, non-randomised, phase 1/2 trial on the safety, tolerability, and immunogenicity of single-dose vaccine “Sputnik Light” for prevention of coronavirus infection in healthy adults / Amir I. Tukhvatulin [et al.] // The Lancet Regional Health – Europe. – 2021. – Vol. 11, Dec. – https://doi.org/10.1016/j.lanepe.2021.100241.An open, non-randomised, phase 1/2 trial on the safety, tolerability, and immunogenicity of single-dose vaccine “Sputnik Light” for prevention of coronavirus infection in healthy adults / Amir I. Tukhvatulin [et al.] // The Lancet Regional Health – Europe. – 2021. – Vol. 11. – https://doi.org/10.1016/j.lanepe.2021.100241.Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants in England / Tommy Nyberg [et al.] // Preprints with The Lancet (2022). – http://dx.doi.org/10.2139/ssrn.4025932.Comparative analysis of the risks of hospitalisation and death associated with SARS-CoV-2 Omicron (B.1.1.529) and Delta (B.1.617.2) variants in England / Tommy Nyberg [et al.] // Preprints with The Lancet. – 2022. http://dx.doi.org/10.2139/ssrn.4025932.COVID-19: vaccination vs. hospitalization / O. Uzun, T. Akpolat, A. Varol [et al.] // Infection. – 2022. – Jan. 4. – Р. 1–6. – https://doi.org/10.1007/s15010-021-01751-1.COVID-19: vaccination vs. hospitalization / O. Uzun, T. Akpolat, A. Varol [et al.] // Infection. – 2022. – Jan. 4. – P. 1–6. – https://doi.org/10.1007/s15010-021-01751-1.COVID-19 vaccines: The status and perspectives in delivery points of view / Jee Young Chunga, Melissa N. Thone, Young Jik Kwon // Adv Drug Deliv Rev. – 2021. – Vol. 170. – Р. 1–25. – doi: 10.1016/j.addr.2020.12.011.COVID-19 vaccines: The status and perspectives in delivery points of view / Jee Young Chung, Melissa N. Thone, Young Jik Kwon // Adv Drug Deliv Rev. – 2021. – Vol. 170. – P. 1–25. – doi: 10.1016/j.addr.2020.12.011.Kirby, T. Has Spain reached herd immunity? / T. Kirby // The Lancet. – 2021. – Vol. 9, Iss. 12. – https://doi.org/10.1016/S2213-2600(21)00495-1.Kirby, T. Has Spain reached herd immunity? / T. Kirby // The Lancet. – 2021. – Vol. 9, Iss. 12. – https://doi.org/10.1016/S2213-2600(21)00495-1.Megha, K. B. Vaccine and vaccination as a part of human life: In view of COVID-19 / K. B. Megha, Seema A. Nayar, P. V. Mohanan // Biotechnol J. – 2022. – Vol. 17(1). – doi: 10.1002/biot.202100188.Megha, K. B. Vaccine and vaccination as a part of human life: In view of COVID-19 / K. B. Megha, Seema A. Nayar, P. V. Mohanan // Biotechnol J. – 2022. – Vol. 17(1). – doi: 10.1002/biot.202100188.Mini-Review Discussing the Reliability and Efficiency of COVID-19 Vaccines / Bogdan Doroftei,Alin Ciobica, OvidiuDumitru Ilie, Radu Maftei, Ciprian Ilea // Diagnostics (Basel). 2021 Mar. 24;11(4):579. – doi: 10.3390/diagnostics11040579.Mini-Review Discussing the Reliability and Efficiency of COVID-19 Vaccines / Bogdan Doroftei,Alin Ciobica, OvidiuDumitru Ilie, Radu Maftei, Ciprian Ilea // Diagnostics (Basel). – 2021. – Mar. 24, Vol. 11(4). – P. 579. – doi: 10.3390/diagnostics11040579.Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants / S. Ikegame, M. N. A. Siddiquey, C. T. Hung [et al.] // Nat Commun. – 2021. 12, 4598. – https://doi.org/10.1038/s41467-021-24909-9.Neutralizing activity of Sputnik V vaccine sera against SARS-CoV-2 variants / S. Ikegame, M. N. A. Siddiquey, C. T. Hung [et al.] // Nat Commun 12, 4598 (2021). – https://doi.org/10.1038/s41467-021-24909-9.Nogrady, B. Mounting evidence suggests Sputnik COVID vaccine is safe and effective / Bianca Nogrady // Nature. – 2021. – Vol. 595. – P. 339–340. – https://doi.org/10.1038/d41586-021-01813-2.Nogrady, B. Mounting evidence suggests Sputnik COVID vaccine is safe and effective / Bianca Nogrady // Nature. – 2021. – Vol. 595. – P. 339–340. – https://doi.org/10.1038/d41586-021-01813-2.The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States / Seyed M. Moghadas [et al.] // Clinical Infectious Diseases. – 2021. – Vol. 73, Iss. 12. – P. 2257–2264. – https://doi.org/10.1093/cid/ciab079.The Impact of Vaccination on Coronavirus Disease 2019 (COVID-19) Outbreaks in the United States / Seyed M. Moghadas [et al.] // Clinical Infectious Diseases. – 2021. – Vol. 73, Iss. 12. – P. 2257–2264. – https://doi.org/10.1093/cid/ciab079.

The authors declare that there are no conflicts of interest present.