<?xml version="1.0" encoding="UTF-8"?>
<!DOCTYPE article PUBLIC "-//NLM//DTD JATS (Z39.96) Journal Publishing DTD v1.3 20210610//EN" "JATS-journalpublishing1-3.dtd">
<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2024.3.142</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-218</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>В ПОМОЩЬ ПРАКТИКУЮЩЕМУ ВРАЧУ</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="en"><subject>TO HELP THE PRACTITIONER</subject></subj-group></article-categories><title-group><article-title>ФОРМИРОВАНИЕ ГРУППЫ ДИСПАНСЕРНОГО НАБЛЮДЕНИЯ ДЕВОЧЕК-ПОДРОСТКОВ С РИСКОМ РАЗВИТИЯ СИНДРОМА ПОЛИКИСТОЗНЫХ ЯИЧНИКОВ</article-title><trans-title-group xml:lang="en"><trans-title>FORMATION OF A FOLLOW-UP GROUP FOR ADOLESCENT GIRLS AT RISK OF DEVELOPING POLYCYSTIC OVARY SYNDROME</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Кириллова</surname><given-names>Е. Н.</given-names></name><name name-style="western" xml:lang="en"><surname>Kirillova</surname><given-names>E. N.</given-names></name></name-alternatives><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>УО «Белорусский государственный медицинский университет»</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2024</year></pub-date><pub-date pub-type="epub"><day>19</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>3</issue><fpage>142</fpage><lpage>147</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Кириллова Е.Н., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Кириллова Е.Н.</copyright-holder><copyright-holder xml:lang="en">Kirillova E.N.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/218">https://medjournal.ejournal.by/jour/article/view/218</self-uri><abstract><p>Синдром поликистозных яичников (СПКЯ) является одним из самых распространенных эндокринно-метаболических нарушений менструальной и репродуктивной функций. Частота распространения среди девочек составляет от 2,2 до 7,5 %, среди женщин репродуктивного возраста – 15 %, а среди пациенток с ановуляторным бесплодием – 73 %. Высокая распространенность данной патологии в женской популяции (до 10 %) ставит её в разряд актуальных медицинских проблем, связанных с развитием первичного бесплодия, гиперпластических процессов эндометрия, ожирения, сердечно-сосудистой патологии. Формирование СПКЯ чаще сопряжено с периодом полового созревания. Характерная для этого возрастного периода неустойчивость синтеза гонадотропинов, физиологическое повышение уровня андрогенов и инсулина являются благоприятным фоном для возникновения СПКЯ [<xref ref-type="bibr" rid="cit1">1</xref>]. Статья посвящена изучению факторов, которые могут оказать влияние на развитие репродуктивной системы и привести к формированию СПКЯ. Изучен социальный, семейный и перинатальный анамнез девочек с формирующимся синдромом поликистозных яичников. Отмечено, что часто их пубертатный период сопровождается целым рядом отклонений: неправильной очередностью формирования вторичных половых признаков, ранним пубархе, ранним и поздним телархе, ранним и поздним менархе. Своевременное выявление таких нарушений лежит в основе формирования группы риска по развитию СПКЯ и профилактики репродуктивных нарушений в дальнейшем.</p></abstract><trans-abstract xml:lang="en"><p>Polycystic ovary syndrome (PCOS) is one of the most common endocrine and metabolic disorders of menstrual and reproductive functions. The prevalence rate among girls ranges from 2.2 to 7.5 %, among women of reproductive age – 15 %, and among patients with anovulatory infertility – 73 %. The high prevalence of this pathology in the female population (up to 10 %) places it among the relevant medical problems associated with the development of primary infertility, endometrial hyperplastic processes, obesity, and cardiovascular pathology. The formation of PCOS is often associated with puberty. The instability of gonadotropin synthesis, characteristic of this age period, and the physiological increase in the level of androgens and insulin are precursory factors for the occurrence of PCOS. The article is devoted to the study of factors that can influence the development of the reproductive system and lead to the formation of PCOS. The social, family and perinatal history of girls with emerging polycystic ovary syndrome was studied. It is noted that their puberty is often accompanied by a number of deviations: incorrect order of formation of secondary sexual characteristics, early pubarche, early and late thelarche, early and late menarche. Timely detection of such disorders underlies the formation of a risk group for the development of PCOS and the prevention of reproductive disorders in the future.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>синдром поликистозных яичников</kwd><kwd>девочки-подростки</kwd><kwd>факторы риска</kwd></kwd-group><kwd-group xml:lang="en"><kwd>polycystic ovary syndrome</kwd><kwd>teenage girls</kwd><kwd>risk factors</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Богатырева, Е. М. Гиперандрогения пубертатного периода. Учебно-методическое пособие / Е. М. Богатырева, Г. Ф. Кутушева, Г. А. Новик. – СПб.: СПбГПМУ, 2018. – 60 с.</mixed-citation><mixed-citation xml:lang="en">Bogatyreva, E. M. Giperandrogeniyapubertatnogo perioda. Uchebno-metodicheskoeposobie / E. M. Bogatyreva, G. F. Kutusheva, G. A. Novik. – SPb.: SPbGPMU, 2018. – 60 р. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Гуркин, Ю. А. Детская и подростковая гинекология: Руководство для врачей / Ю. А. Гуркин – М.: ООО «Медицинское информационное агентство», 2009. – 696 с.</mixed-citation><mixed-citation xml:lang="en">Gurkin, U. A. Detskaya i podrostkovaya ginekologiya: Rukovodstvo dlya vrachej / U. A. Gurkin – M.: OOO «Medicinskoe informacionnoe agentstvo», 2009. – 696 p. (in Russian).</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Кириллова, Е. Н. Стимуляция овуляции у женщин с синдромом поликистозных яичников / Е. Н. Кириллова, А. А. Генералова // Мед. журн. – 2013. – Т. 43, № 1. – С. 139–141.</mixed-citation><mixed-citation xml:lang="en">Kirillova, E. N. Stimuliatsiiaovuliatsii u zhenshchin s sindromompolikistoznykhiaichnikov / E. N. Kirillova, A. A. Generalova // Med. zhurn. – 2013. – Vol. 43, № 1. – S. 139–141.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Chittenden, B. G. Policystic Ovary Syndrome and Risk of Gynaecological Cancer: A Systematic Review / B. Chittenden, G. Fullerton, A. Maheshwari, S. Bhatta-charya // Reprod. Biomed. – 2009. – № 3 (Sep). – Р. 398–405.</mixed-citation><mixed-citation xml:lang="en">Chittenden, B. G. Policystic Ovary Syndrome and Risk of Gynaecological Cancer: A Systematic Review / B. Chittenden, G. Fullerton, A. Maheshwari, S. Bhattacharya // Reprod. Biomed. – 2009. – № 3 (Sep). – Р. 398–405.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">Lizneva, D. Criteria, prevalence, and phenotypes of polycystic ovarysyndrom / D. Lizneva, L. Suturina, W. Walker, S. Brakta, L. Gavrilova-Jordan, R. Azziz // Fertil. Steril. – 2016. – Vol. 106, № 1. – P. 6–15.</mixed-citation><mixed-citation xml:lang="en">Lizneva, D. Criteria, prevalence, and phenotypes of polycystic ovarysyndrom / D. Lizneva, L. Suturina, W. Walker, S. Brakta, L. Gavrilova-Jordan, R. Azziz // Fertil. Steril. – 2016. – Vol. 106, № 1. – P. 6–15.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Miller, W. L. The post-translational regulation of 17,20lyase activity / W. L. Miller, M. K. Tee // Mol. Cell Endocrinol. – 2015. – Vol. 408, № 8. – P. 99–106.</mixed-citation><mixed-citation xml:lang="en">Miller, W. L. The post-translational regulation of 17,20lyase activity / W. L. Miller, M. K. Tee // Mol. Cell Endocrinol. – 2015. – Vol. 408, № 8. – P. 99–106.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rosenfield, R. L. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood / R. L. Rosenfield, D. A. Ehrmann, E. E. Littlejohn // J. Clin. Endocrinol. Metab. – 2015. – Vol. 100, № 4. – P. 1537–1543.</mixed-citation><mixed-citation xml:lang="en">Rosenfield, R. L. Adolescent polycystic ovary syndrome due to functional ovarian hyperandrogenism persists into adulthood / R. L. Rosenfield, D. A. Ehrmann, E. E. Littlejohn // J. Clin. Endocrinol. Metab. – 2015. – Vol. 100, № 4. – P 1537–1543.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome // Fertil. Steril. – 2004. – Vol. 81, № 1. – P. 19–25.</mixed-citation><mixed-citation xml:lang="en">Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group. Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome // Fertil. Steril. – 2004. – Vol. 81, № 1. – P. 19–25.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Villarroel, C. Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents / C. Villarroel, P. Lopez, P. M. Merino // Gynecol. Endocrinol. – 2015. – Vol. 31, № 8. – P. 625–629.</mixed-citation><mixed-citation xml:lang="en">Villarroel, C. Hirsutism and oligomenorrhea are appropriate screening criteria for polycystic ovary syndrome in adolescents / C. Villarroel, P. Lopez, P. M. Merino // Gynecol. Endocrinol. – 2015. – Vol. 31, № 8. – P. 625–629.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
