medjournalМедицинский журналMedical Journal1818-426XБелорусский государственный медицинский университет10.51922/1818-426X.2023.2.113medjournal-170Research ArticleОРИГИНАЛЬНЫЕ НАУЧНЫЕ ПУБЛИКАЦИИORIGINAL SCIENTIFIC PUBLICATIONSОценка клинико-лабораторных характеристик пациентов с тяжелым течением COVID-19 инфекции: акцент на госпитальную гипергликемиюAssessment of clinical and laboratory characteristics in patients with severe COVID-19 infection: focus on hospital hyperglycemiaШепелькевичА. П.ShepelkevichA. P.

г. Минск

ЕфремоваМ. А.EfremovaM. A.

г. Минск

ДыдышкоЮ. В.DydyshkoY. V.

г. Минск

КарповИ. А.KarpovI. A.

г. Минск

ЛитвинчукД. В.LitvinchukD. V.

г. Минск

ЮреняЕ. В.YurenyaE. V.

г. Минск

ШишкоО. Н.ShishkoO. N.

г. Минск

КузьменковаЕ. И.KuzmenkovaE. I.

г. Минск

Бруцкая-СтемпковскаяЕ. В.Brutskaya-StempkovskayaE. V.

г. Минск

ЛобашоваВ. Л.LobashovaV. L.

г. Минск

УО «Белорусский государственный медицинский университет»BelarusУЗ «Минский городской клинический эндокринологический центр»BelarusГУ «Республиканский центр медицинской реабилитации и бальнеолечения»Belarus20231806202502113119Copyright © Шепелькевич А.П., Ефремова М.А., Дыдышко Ю.В., Карпов И.А., Литвинчук Д.В., Юреня Е.В., Шишко О.Н., Кузьменкова Е.И., Бруцкая-Стемпковская Е.В., Лобашова В.Л., 20252025Шепелькевич А.П., Ефремова М.А., Дыдышко Ю.В., Карпов И.А., Литвинчук Д.В., Юреня Е.В., Шишко О.Н., Кузьменкова Е.И., Бруцкая-Стемпковская Е.В., Лобашова В.Л.Shepelkevich A.P., Efremova M.A., Dydyshko Y.V., Karpov I.A., Litvinchuk D.V., Yurenya E.V., Shishko O.N., Kuzmenkova E.I., Brutskaya-Stempkovskaya E.V., Lobashova V.L.Данная работа распространяется под лицензией Creative Commons Attribution 4.0.This work is licensed under a Creative Commons Attribution 4.0 License.https://medjournal.ejournal.by/jour/article/view/170

В статье представлены результаты собственных исследований клинико-анамнестических и лабораторных параметров у пациентов с тяжелым течением COVID-19 с целью выявления возможных предикторов неблагоприятного исхода заболевания у пациентов с сахарным диабетом и гипергликемией. Выполнен ретроспективный анализ данных первичной медицинской документации 320 пациентов, которые получали медицинскую помощь в условиях отделения интенсивной терапии и реанимации инфекционного стационара г. Минска в период с июня 2020 по март 2022 года. Согласно результатам проведенного исследования 70 % пациентов с тяжелым течением COVID-19 имели впервые выявленную гипергликемию, и с 4-х суток у пациентов с неблагоприятным исходом отмечена тенденция к стойкой гипергликемии, что потенциально свидетельствует о ее роли в качестве прогностического параметра.

The article presents the results of our own studies of clinical, anamnestic and laboratory parameters in patients with severe COVID-19. The aim of the study was to identify possible clinical and laboratory predictors of an unfavorable outcome of a severe course of Covid-19 in patients with diabetes mellitus and hyperglycemia. A retrospective analysis of data from primary medical records of 320 patients was performed. All patients received medical care in the intensive care unit of the infectious hospital in Minsk from June 2020 to March 2022. Based on the results of the assessment of glycemic parameters, all patients were divided into the following groups: 224 people with hospital hyperglycemia (HH), 51 patients with a history of diabetes mellitus (DM) and/or newly diagnosed and 45 people without glycemic disorders. Covid-19 infection confirmed by a positive PCR or antigen test from respiratory swabs. Patients with HH and DM had higher levels of ESR, procalcitonin, CRP, LDH, neutrophils, more pronounced lymphopenia, which indicated a more pronounced inflammatory process. The level of D-dimers was assessed as a biomarker of the coagulopathy process, it was also higher in the groups of patients with DM and HH. According to the results of the study, 70 % of patients with severe COVID-19 had newly diagnosed hyperglycemia, and from day 4, patients with an unfavorable outcome showed a tendency to persistent hyperglycemia, which potentially indicates its role as a prognostic parameter.

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The authors declare that there are no conflicts of interest present.