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<article article-type="research-article" dtd-version="1.3" xmlns:mml="http://www.w3.org/1998/Math/MathML" xmlns:xlink="http://www.w3.org/1999/xlink" xmlns:xsi="http://www.w3.org/2001/XMLSchema-instance" xml:lang="ru"><front><journal-meta><journal-id journal-id-type="publisher-id">medjournal</journal-id><journal-title-group><journal-title xml:lang="ru">Медицинский журнал</journal-title><trans-title-group xml:lang="en"><trans-title>Medical Journal</trans-title></trans-title-group></journal-title-group><issn pub-type="ppub">1818-426X</issn><publisher><publisher-name>Белорусский государственный медицинский университет</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="doi">10.51922/1818-426X.2022.4.138</article-id><article-id custom-type="elpub" pub-id-type="custom">medjournal-164</article-id><article-categories><subj-group subj-group-type="heading"><subject>Research Article</subject></subj-group><subj-group subj-group-type="section-heading" xml:lang="ru"><subject>Клинический случай</subject></subj-group></article-categories><title-group><article-title>Причины инфицирования вирусом гепатита С</article-title><trans-title-group xml:lang="en"><trans-title>Causes of hepatitis С infection</trans-title></trans-title-group></title-group><contrib-group><contrib contrib-type="author" corresp="yes"><name-alternatives><name name-style="eastern" xml:lang="ru"><surname>Юркевич</surname><given-names>И. В.</given-names></name><name name-style="western" xml:lang="en"><surname>Yurkevich</surname><given-names>I. V.</given-names></name></name-alternatives><bio xml:lang="ru"><p>Минск</p></bio><xref ref-type="aff" rid="aff-1"/></contrib></contrib-group><aff xml:lang="ru" id="aff-1"><institution>6 городская клиническая больница</institution><country>Belarus</country></aff><pub-date pub-type="collection"><year>2022</year></pub-date><pub-date pub-type="epub"><day>18</day><month>06</month><year>2025</year></pub-date><volume>0</volume><issue>4</issue><fpage>138</fpage><lpage>143</lpage><permissions><copyright-statement>Copyright &amp;#x00A9; Юркевич И.В., 2025</copyright-statement><copyright-year>2025</copyright-year><copyright-holder xml:lang="ru">Юркевич И.В.</copyright-holder><copyright-holder xml:lang="en">Yurkevich I.V.</copyright-holder><license xml:lang="ru" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>Данная работа распространяется под лицензией Creative Commons Attribution 4.0.</license-p></license><license xml:lang="en" license-type="creative-commons-attribution" xlink:href="https://creativecommons.org/licenses/by/4.0/" xlink:type="simple"><license-p>This work is licensed under a Creative Commons Attribution 4.0 License.</license-p></license></permissions><self-uri xlink:href="https://medjournal.ejournal.by/jour/article/view/164">https://medjournal.ejournal.by/jour/article/view/164</self-uri><abstract><p>Цель. Анализ наиболее вероятных причин инфицирования вирусом гепатита С (ВГС), полученных на основании данных эпидемиологического анамнеза пациентов. Материалы и методы. Обследовано 91 пациент, страдающих различными форма  ми ВГС-инфекции, у которых при сборе эпидемиологического анамнеза акцент делался на использование инъекционных психоактивных веществ, наличие гемотрансфузий, хирургических вмешательств, инвазивных лечебно-диагностических процедур, гемодиализ, трансплантация внутренних органов или костного мозга, нанесение татуировок, пирсинг, маникюр в местах лишения свободны, домашних условиях, других учреждениях с использованием потенциально не стерильных инструментов, контакт с кровью пациента с подтвержденным вирусным гепатитом С, незащищенные половые контакты. Результаты. Наиболее распространенными сочетаниями являются хирургические вмешательства с гемотрансфузией, парамедицинские манипуляции, хирургические вмешательства или инвазивные диагностические вмешательства. Заключение. В настоящее время парамедицинские манипуляции стали значимым фактором передачи ВГС.</p></abstract><trans-abstract xml:lang="en"><p>Purpose. Analysis of the most probable causes of infection with the hepatitis C virus (HCV), obtained on the basis of epidemiological history of patients. Materials and methods. We examined 91 patients suffering from various forms of HCV infection, in whom, when collecting an epidemiological history, the emphasis was on the use of injectable psychoactive substances, the presence of blood transfusions, surgical interventions, invasive medical and diagnostic procedures, hemodialysis, transplantation of internal organs or bone marrow, tattooing, piercing , manicure in places of deprivation is free, at home, other institutions   using potentially non-sterile instruments, contact with the blood of a patient with confirmed viral hepatitis C, unprotected sex. Results. The most common combinations are surgery with blood transfusion, paramedical procedures, surgical interventions or invasive diagnostic interventions. Conclusion. Currently, paramedical manipulations are the dominant factors.</p></trans-abstract><kwd-group xml:lang="ru"><kwd>вирусный гепатит С</kwd><kwd>эпидемиология</kwd><kwd>инфицирование</kwd><kwd>парамедицинские манипуляции</kwd><kwd>инвазивные вмешательства</kwd></kwd-group><kwd-group xml:lang="en"><kwd>viral hepatitis C</kwd><kwd>epidemiology</kwd><kwd>infection</kwd><kwd>paramedical manipulations</kwd><kwd>invasive procedures</kwd></kwd-group></article-meta></front><back><ref-list><title>References</title><ref id="cit1"><label>1</label><citation-alternatives><mixed-citation xml:lang="ru">Choo, Q. L., Kuo G., Weiner A. J., et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome // Science. – 1989. – Vol. 244(4902). – P. 359–362. – DOI: 10.1126/science.2523562.</mixed-citation><mixed-citation xml:lang="en">Choo, Q. L., Kuo G., Weiner A. J., et al. Isolation of a cDNA clone derived from a blood-borne non-A, non-B viral hepatitis genome // Science. – 1989. – Vol. 244(4902). – P. 359–362. DOI: 10.1126/science.2523562.</mixed-citation></citation-alternatives></ref><ref id="cit2"><label>2</label><citation-alternatives><mixed-citation xml:lang="ru">Lozano, R., Naghavi M., Foreman K., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 // Lancet. – 2012. – Vol. 380(9859). – P. 2095–2128. – DOI: 10.1016/S0140-6736(12)61728-0.</mixed-citation><mixed-citation xml:lang="en">Lozano, R., Naghavi M., Foreman K., et al. Global and regional mortality from 235 causes of death for 20 age groups in 1990 and 2010: a systematic analysis for the Global Burden of Disease Study 2010 // Lancet. – 2012. – Vol. 380(9859). – P. 2095–2128. – DOI: 10.1016/S0140-6736(12)61728-0.</mixed-citation></citation-alternatives></ref><ref id="cit3"><label>3</label><citation-alternatives><mixed-citation xml:lang="ru">Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 // Lancet. – 2015. – Vol. 386(9995). – P. 743–800. – DOI: 10.1016/S0140-6736(15)60692-4.</mixed-citation><mixed-citation xml:lang="en">Global Burden of Disease Study 2013 Collaborators. Global, regional, and national incidence, prevalence, and years lived with disability for 301 acute and chronic diseases and injuries in 188 countries, 1990–2013: a systematic analysis for the Global Burden of Disease Study 2013 // Lancet. – 2015. – Vol. 386(9995). – P. 743–800. – DOI: 10.1016/S0140-6736(15)60692-4.</mixed-citation></citation-alternatives></ref><ref id="cit4"><label>4</label><citation-alternatives><mixed-citation xml:lang="ru">Hepatitis C. WHO Fact sheets. 2022. Avilable at: https://www.who.int/ru/news-room/fact-sheets/detail/hepatitis-c.</mixed-citation><mixed-citation xml:lang="en">Hepatitis C. WHO Fact sheets. 2022. Avilable at: https://www.who.int/ru/news-room/fact-sheets/detail/hepatitis-c.</mixed-citation></citation-alternatives></ref><ref id="cit5"><label>5</label><citation-alternatives><mixed-citation xml:lang="ru">El-Ghitany, E. M., Abdel Wahab M. M., Abd El-Wahab E. W., et al. A comprehensive hepatitis C virus risk factors metaanalysis (1989–2013): do they differ in Egypt? // Liver Int. – 2015. – Vol. 35(2). – P. 489–501. – DOI: 10.1111/liv.12617.</mixed-citation><mixed-citation xml:lang="en">El-Ghitany, E. M., Abdel Wahab M. M., Abd El-Wahab E. W., et al. A comprehensive hepatitis C virus risk factors metaanalysis (1989–2013): do they differ in Egypt? // Liver Int. – 2015. – № 35(2). – P. 489–501. – DOI: 10.1111/liv.12617.</mixed-citation></citation-alternatives></ref><ref id="cit6"><label>6</label><citation-alternatives><mixed-citation xml:lang="ru">Sohn, H. S., Kim J. R., Ryu S. Y., et al. Risk Factors for Hepatitis C Virus (HCV) Infection in Areas with a High Prevalence of HCV in the Republic of Korea in 2013 // Gut Liver. – 2016. – № 10(1). – P. 126–132. – DOI: 10.5009/gnl14403.</mixed-citation><mixed-citation xml:lang="en">Sohn, H. S., Kim J. R., Ryu S. Y., et al. Risk Factors for Hepatitis C Virus (HCV) Infection in Areas with a High Prevalence of HCV in the Republic of Korea in 2013 // Gut Liver. – 2016. – Vol. 10(1). – Р. 126–132. – DOI: 10.5009/gnl14403.</mixed-citation></citation-alternatives></ref><ref id="cit7"><label>7</label><citation-alternatives><mixed-citation xml:lang="ru">Rerambiah, L. K., Rerambiah L. E., Bengone C., et al. The risk of transfusion-transmitted viral infections at the Gabonese National Blood Transfusion Centre // Blood Transfus. – 2014 . – № 12(3). – Р. 330–333. – DOI: 10.2450/2013.0144-13.</mixed-citation><mixed-citation xml:lang="en">Rerambiah, L. K., Rerambiah L. E., Bengone C., et al. The risk of transfusion-transmitted viral infections at the Gabonese National Blood Transfusion Centre // Blood Transfus. – 2014. – Vol. 12(3). – Р. 330–333. – DOI: 10.2450/2013.0144-13.</mixed-citation></citation-alternatives></ref><ref id="cit8"><label>8</label><citation-alternatives><mixed-citation xml:lang="ru">Eze, J. C., Ibeziako N. S., Ikefuna A. N., et al. Prevalence and risk factors for hepatitis C and human immunodeficiency virus coinfection among children in enugu, Nigeria // Afr J Infect Dis. – 2014. – № 8(1). – Р. 5–8. – DOI: 10.4314/ajid.v8i1.2.</mixed-citation><mixed-citation xml:lang="en">Eze, J. C., Ibeziako N. S., Ikefuna A. N., et al. Prevalence and risk factors for hepatitis C and human immunodeficiency virus coinfection among children in enugu, Nigeria // Afr J Infect Dis. – 2014. – № 8(1). – Р. 5–8. – DOI: 10.4314/ajid.v8i1.2.</mixed-citation></citation-alternatives></ref><ref id="cit9"><label>9</label><citation-alternatives><mixed-citation xml:lang="ru">Kane, A., Lloyd J., Zaffran M., et al. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates // Bull World Health Organ. – 1999. – № 77(10). – Р. 801–807.</mixed-citation><mixed-citation xml:lang="en">Kane, A., Lloyd J., Zaffran M., et al. Transmission of hepatitis B, hepatitis C and human immunodeficiency viruses through unsafe injections in the developing world: model-based regional estimates // Bull World Health Organ. – 1999. – Vol. 77(10). – Р. 801–807.</mixed-citation></citation-alternatives></ref><ref id="cit10"><label>10</label><citation-alternatives><mixed-citation xml:lang="ru">Pépin, J., Abou Chakra C. N., Pépin E., et al. Evolution of the global burden of viral infections from unsafe medical injections, 2000–2010 // PLoS One. – 2014. – № 9(6). – Р. e99677. – DOI: 10.1371/journal.pone.0099677.</mixed-citation><mixed-citation xml:lang="en">Pépin, J., Abou Chakra C. N., Pépin E., et al. Evolution of the global burden of viral infections from unsafe medical injections, 2000–2010 // PLoS One. – 2014. – № 9(6). – Р.e99677. – DOI: 10.1371/journal.pone.0099677.</mixed-citation></citation-alternatives></ref><ref id="cit11"><label>11</label><citation-alternatives><mixed-citation xml:lang="ru">Global database on blood safety. In: Blood transfusion safety. World Health Organization. 2011. Avilable at: http://www.who.int/bloodsafety/global_database/en.</mixed-citation><mixed-citation xml:lang="en">Global database on blood safety. In: Blood transfusion safety. World Health Organization. 2011. Avilable at: http://www.who.int/bloodsafety/global_database/en.</mixed-citation></citation-alternatives></ref><ref id="cit12"><label>12</label><citation-alternatives><mixed-citation xml:lang="ru">CDC Healthcare-Associated Hepatitis B and C Outbreaks Reported to the Centers for Disease Control and Prevention (CDC) 2008–2014. Available at: http://www.cdc.gov/hepatitis/outbreaks/healthcarehepoutbreaktable.htm.</mixed-citation><mixed-citation xml:lang="en">CDC Healthcare-Associated Hepatitis B and C Outbreaks Reported to the Centers for Disease Control and Prevention (CDC) 2008–2014. Available at: http://www.cdc.gov/hepatitis/outbreaks/healthcarehepoutbreaktable.htm.</mixed-citation></citation-alternatives></ref><ref id="cit13"><label>13</label><citation-alternatives><mixed-citation xml:lang="ru">de Lédinghen, V., Trimoulet P., Mannant P. R., et al. Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years) // J Hepatol. – 2007. – № 46(1). – Р. 19–25. – DOI: 10.1016/j.jhep.2006.07.029.</mixed-citation><mixed-citation xml:lang="en">de Lédinghen, V., Trimoulet P., Mannant P. R., et al. Outbreak of hepatitis C virus infection during sclerotherapy of varicose veins: long-term follow-up of 196 patients (4535 patient-years) // J Hepatol. – 2007. – Vol. 46(1). – P. 19–25. – DOI: 10.1016/j.jhep.2006.07.029.</mixed-citation></citation-alternatives></ref><ref id="cit14"><label>14</label><citation-alternatives><mixed-citation xml:lang="ru">Lanini, S., Abbate I., Puro V., et al. Molecular epidemiology of a hepatitis C virus epidemic in a haemodialysis unit: outbreak investigation and infection outcome // BMC Infect Dis. – 2010. – № 10. – Р. 257. – DOI: 10.1186/1471-2334-10-257.</mixed-citation><mixed-citation xml:lang="en">Lanini, S., Abbate I., Puro V., et al. Molecular epidemiology of a hepatitis C virus epidemic in a haemodialysis unit: outbreak investigation and infection outcome // BMC Infect Dis. – 2010. – № 10. – P. 257. – DOI: 10.1186/1471-2334-10-257.</mixed-citation></citation-alternatives></ref><ref id="cit15"><label>15</label><citation-alternatives><mixed-citation xml:lang="ru">Ross, R. S., Viazov S., Khudyakov Y. E., et al. Transmission of hepatitis C virus in an orthopedic hospital ward // J Med Virol. – 2009. – № 81(2). – Р. 249–257. – DOI: 10.1002/jmv.21394.</mixed-citation><mixed-citation xml:lang="en">Ross, R. S., Viazov S., Khudyakov Y. E., et al. Transmission of hepatitis C virus in an orthopedic hospital ward // J Med Virol. – 2009. – Vol. 81(2). – P. 249–257. – DOI: 10.1002/jmv.21394.</mixed-citation></citation-alternatives></ref><ref id="cit16"><label>16</label><citation-alternatives><mixed-citation xml:lang="ru">Martínez-Bauer, E., Forns X., Armelles M., et al. Hospital admission is a relevant source of hepatitis C virus acquisition in Spain // J Hepatol. – 2008. – № 48(1). – Р. 20–7. – DOI: 10.1016/j.jhep.2007.07.031.</mixed-citation><mixed-citation xml:lang="en">Martínez-Bauer, E., Forns X., Armelles M., et al. Hospital admission is a relevant source of hepatitis C virus acquisition in Spain // J Hepatol. – 2008. – Vol. 48(1). – Р. 20–7. – DOI: 10.1016/j.jhep.2007.07.031.</mixed-citation></citation-alternatives></ref><ref id="cit17"><label>17</label><citation-alternatives><mixed-citation xml:lang="ru">Terrault, N. A., Dodge J. L., Murphy E. L., et al. Sexual transmission of hepatitis C virus among monogamous hetero sexual couples: the HCV partners study // Hepatology. – 2013. – № 57(3). – Р. 881–889. – DOI: 10.1002/hep.26164.</mixed-citation><mixed-citation xml:lang="en">Terrault, N. A., Dodge J. L., Murphy E. L., et al. Sexual transmission of hepatitis C virus among monogamous heterosexual couples: the HCV partners study // Hepatology. – 2013. – Vol. 57(3). – Р. 881–889. – DOI: 10.1002/hep.26164.</mixed-citation></citation-alternatives></ref><ref id="cit18"><label>18</label><citation-alternatives><mixed-citation xml:lang="ru">Hullegie, S. J., van den Berk G. E. L., Leyten E. M. S., et al. Acute hepatitis C in the Netherlands: characteristics of the epidemic in 2014 // Clin Microbiol Infect. – 2016. – № 22(2). – Р. 209.e1–209.e3. – DOI: 10.1016/j.cmi.2015.10.012.</mixed-citation><mixed-citation xml:lang="en">Hullegie, S. J., van den Berk G. E.L., Leyten E. M.S., et al. Acute hepatitis C in the Netherlands: characteristics of the epidemic in 2014 // Clin Microbiol Infect. – 2016. – № 22(2). – Р. 209.e1–209.e3. – DOI: 10.1016/j.cmi.2015.10.012.</mixed-citation></citation-alternatives></ref><ref id="cit19"><label>19</label><citation-alternatives><mixed-citation xml:lang="ru">Martin, N. K., Thornton A., Hickman M., et al. Can Hepatitis C Virus (HCV) Direct-Acting Antiviral Treatment as Prevention Reverse the HCV Epidemic Among Men Who Have Sex With Men in the United Kingdom? Epidemiological and Modeling Insights // Clin Infect Dis. – 2016. – № 62(9). – Р. 1072–1080. – DOI: 10.1093/cid/ciw075.</mixed-citation><mixed-citation xml:lang="en">Martin, N. K., Thornton A., Hickman M., et al. Can Hepatitis C Virus (HCV) Direct-Acting Antiviral Treatment as Prevention Reverse the HCV Epidemic Among Men Who Have Sex With Men in the United Kingdom? Epidemiological and Modeling Insights // Clin Infect Dis. – 2016. – Vol. 62(9). – Р. 1072–1080. – DOI: 10.1093/cid/ciw075.</mixed-citation></citation-alternatives></ref><ref id="cit20"><label>20</label><citation-alternatives><mixed-citation xml:lang="ru">Vanhommerig, J. W., Lambers F. A., Schinkel J., et al. Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study // Open Forum Infect Dis. – 2015 – № 2(3). – Р. ofv115. – DOI: 10.1093/ofid/ofv115.</mixed-citation><mixed-citation xml:lang="en">Vanhommerig, J. W., Lambers F. A., Schinkel J., et al. Risk Factors for Sexual Transmission of Hepatitis C Virus Among Human Immunodeficiency Virus-Infected Men Who Have Sex With Men: A Case-Control Study // Open Forum Infect Dis. – 2015. – № 2(3). – Р. ofv115. – DOI: 10.1093/ofid/ofv115.</mixed-citation></citation-alternatives></ref></ref-list><fn-group><fn fn-type="conflict"><p>The authors declare that there are no conflicts of interest present.</p></fn></fn-group></back></article>
